SIMULATION OF PENTAPEPTIDE DRUG INTERACTION WITH β-SHEET-RICH MONOMERS OF Aβ PROTEIN FOR ALZHEIMER TREATMENT

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KHANDAN V.; FIROOZABADI B.; SAEIDI M.S.

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Paper Information

Journal: IRANIAN JOURNAL OF BIOMEDICAL ENGINEERING Year:2014 | Volume:8 | Issue:3 Page(s): 229-239

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Information Journal Paper

Title

SIMULATION OF PENTAPEPTIDE DRUG INTERACTION WITH β-SHEET-RICH MONOMERS OF Aβ PROTEIN FOR ALZHEIMER TREATMENT

Author(s)

KHANDAN V. | FIROOZABADI B. | SAEIDI M.S. | Issue Writer Certificate

Keywords

ALZHEIMER’S DISEASE (AD)Q1

AMYLOID BETA (AΒ)Q2

β-SHEET BREAKERQ2

DOCKINGQ2

MOLECULAR DYNAMICS (MD)Q2

Abstract

A hallmark of Alzheimer disease (the most common type of dementia in the elderly) is the aggregation and deposition of toxic species ranging from small soluble oligomers to insoluble fibril plaques of Amyloid-Beta protein originates from the cleavage of APP by Beta and Gama Secretase (Amyloid Hypothesis). An attractive therapeutic approach to treat AD is to identify small ligands capable of binding to A-Beta monomers and reverse its amyloidosis process. Here, a peptide drug having the sequence of GLMVG which has been derived from the C-terminal of A-Beta was used as breaker for a monomer of Beta sheet rich structure. The combination of DOCKING and Molecular Dynamics methods were used for simulation of drug-receptor interaction. This simulation implied that pent apeptide altered secondary structure of A-Beta monomer and declined its stability. This study proved that pent apeptide is capable to reverse Beta-sheet formation and can be considered as an AD drug in other preclinical studies.

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APA: Copy

KHANDAN, V., FIROOZABADI, B., & SAEIDI, M.S.. (2014). SIMULATION OF PENTAPEPTIDE DRUG INTERACTION WITH β-SHEET-RICH MONOMERS OF Aβ PROTEIN FOR ALZHEIMER TREATMENT. IRANIAN JOURNAL OF BIOMEDICAL ENGINEERING, 8(3), 229-239. SID. https://sid.ir/paper/81607/en

Vancouver: Copy

KHANDAN V., FIROOZABADI B., SAEIDI M.S.. SIMULATION OF PENTAPEPTIDE DRUG INTERACTION WITH β-SHEET-RICH MONOMERS OF Aβ PROTEIN FOR ALZHEIMER TREATMENT. IRANIAN JOURNAL OF BIOMEDICAL ENGINEERING[Internet]. 2014;8(3):229-239. Available from: https://sid.ir/paper/81607/en

IEEE: Copy

V. KHANDAN, B. FIROOZABADI, and M.S. SAEIDI, “SIMULATION OF PENTAPEPTIDE DRUG INTERACTION WITH β-SHEET-RICH MONOMERS OF Aβ PROTEIN FOR ALZHEIMER TREATMENT,” IRANIAN JOURNAL OF BIOMEDICAL ENGINEERING, vol. 8, no. 3, pp. 229–239, 2014, [Online]. Available: https://sid.ir/paper/81607/en

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