Numerical Modeling of the Temperature-responsive Multi-layer Smart Drug delivery System at Unsteady State

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SIROUSAZAR M.; ZEBARDAST H.; Hosseini Dastgerdi z.; KHEIRI F.

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Journal: IRANIAN JOURNAL OF BIOMEDICAL ENGINEERING Year:2020 | Volume:13 | Issue:4 Page(s): 363-374

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Title

Numerical Modeling of the Temperature-responsive Multi-layer Smart Drug delivery System at Unsteady State

Author(s)

SIROUSAZAR M. | ZEBARDAST H. | Hosseini Dastgerdi z. | KHEIRI F. | Issue Writer Certificate

Keywords

Smart Drug DeliveryQ1

Numerical ModelingQ1

unsteady StateQ1

Heat TransferQ2

Mass transferQ1

Abstract

In this research, the response of a novel drug delivery system responsive to the temperature, as a unique stimulus, was studied. The performance of the system was modeled at the unsteady State, using the numerical method. The system has three individual layers, containing a drug core, a phase-transient intermediate layer and an external protective layer. The system has the ability to start and stop the release of the drug, according to the On-Off mechanism, by exerting any changes in the temperature of the release medium. Mathematical modeling was performed by solving the heat and Mass transfer equations governing the layers of the system at the unsteady State. The lag time of system at On state, the drug release kinetics at On state and undesired drug release kinetics at Off state were determined as functions of the parameters of the system. The results obtained from the modeling showed that response of the system was under the influence of different parameters, such as the geometry of the system, the kind of constituents of the intermediate and protective layers and the ratio of the thermal conductivity of the intermediate layer at molten state to the thermal conductivity of the protective layer. It was shown that a reduced lag time for the system could be achieved by manipulating these parameters. From the viewpoint of the drug release kinetics at On state, it could be declared that the amount of the released drug is a function of the time constant of the system and the drug release could be increased by decreasing the time constant value. The results also showed that the undesired release of the drug could be accelerated by adjusting the parameters of the protective layer, such as the kind of constituents and the thickness of the layer. Using the obtained results from the Numerical Modeling, one can design and produce the temperature-responsive Smart Drug Delivery systems with desired characteristics for practical applications.

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APA: Copy

SIROUSAZAR, M., ZEBARDAST, H., Hosseini Dastgerdi, z., & KHEIRI, F.. (2020). Numerical Modeling of the Temperature-responsive Multi-layer Smart Drug delivery System at Unsteady State. IRANIAN JOURNAL OF BIOMEDICAL ENGINEERING, 13(4 ), 363-374. SID. https://sid.ir/paper/81617/en

Vancouver: Copy

SIROUSAZAR M., ZEBARDAST H., Hosseini Dastgerdi z., KHEIRI F.. Numerical Modeling of the Temperature-responsive Multi-layer Smart Drug delivery System at Unsteady State. IRANIAN JOURNAL OF BIOMEDICAL ENGINEERING[Internet]. 2020;13(4 ):363-374. Available from: https://sid.ir/paper/81617/en

IEEE: Copy

M. SIROUSAZAR, H. ZEBARDAST, z. Hosseini Dastgerdi, and F. KHEIRI, “Numerical Modeling of the Temperature-responsive Multi-layer Smart Drug delivery System at Unsteady State,” IRANIAN JOURNAL OF BIOMEDICAL ENGINEERING, vol. 13, no. 4 , pp. 363–374, 2020, [Online]. Available: https://sid.ir/paper/81617/en

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