SIMULATION OF NEUROTRANSMITTER RELEASE AT THE NEUROMUSCULAR JUNCTION

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MAHMOUDI M.; KHATIBIRAD S.; ABD KHODAEI M.J.

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Journal: IRANIAN JOURNAL OF BIOMEDICAL ENGINEERING Year:2005 | Volume:2 | Issue:1 Page(s): 9-16

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Title

SIMULATION OF NEUROTRANSMITTER RELEASE AT THE NEUROMUSCULAR JUNCTION

Author(s)

MAHMOUDI M. | KHATIBIRAD S. | ABD KHODAEI M.J. | Issue Writer Certificate

Keywords

SYNAPSEQ4

NEUROMUSCULAR JUNCTIONQ4

NEUROTRANSMITTERQ4

SYNAPTIC VESICLEQ2

SIMULATIONQ2

MODELINGQ2

Abstract

A mathematical model is presented for SIMULATION of NEUROTRANSMITTER release in the synaptic cleft of a NEUROMUSCULAR JUNCTION. Chaudhuri's model is improved by adding calcium diffusion effect on the NEUROTRANSMITTER release. When an action potential occurs, the calcium channels on presynaptic membrane will open and allow calcium ions to enter in presynaptic terminal. Then, these ions diffuse between calcium channels and release sites, where clearance mechanisms remove some of them. The model is defined by some partial differential equations which are solved by numerical methods. Solving these equations, the temporal changes of calcium concentration in the release sites and the amount of NEUROTRANSMITTER release at each time are obtained. Finally, the effect of two consecutive action potential pulses on the above mechanisms is studied.

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APA: Copy

MAHMOUDI, M., KHATIBIRAD, S., & ABD KHODAEI, M.J.. (2005). SIMULATION OF NEUROTRANSMITTER RELEASE AT THE NEUROMUSCULAR JUNCTION. IRANIAN JOURNAL OF BIOMEDICAL ENGINEERING, 2(1), 9-16. SID. https://sid.ir/paper/81682/en

Vancouver: Copy

MAHMOUDI M., KHATIBIRAD S., ABD KHODAEI M.J.. SIMULATION OF NEUROTRANSMITTER RELEASE AT THE NEUROMUSCULAR JUNCTION. IRANIAN JOURNAL OF BIOMEDICAL ENGINEERING[Internet]. 2005;2(1):9-16. Available from: https://sid.ir/paper/81682/en

IEEE: Copy

M. MAHMOUDI, S. KHATIBIRAD, and M.J. ABD KHODAEI, “SIMULATION OF NEUROTRANSMITTER RELEASE AT THE NEUROMUSCULAR JUNCTION,” IRANIAN JOURNAL OF BIOMEDICAL ENGINEERING, vol. 2, no. 1, pp. 9–16, 2005, [Online]. Available: https://sid.ir/paper/81682/en

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