FAST RESPONSIVE THERMOSENSITIVE HYDROGELS AS DRUG DELIVERY SYSTEMS

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KHORAM M.; VASHEGHANI FARAAHANI E.; GOLSHAN EBRAHIMI N.

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Journal Paper

Paper Information

Journal: Iranian Polymer Journal Year:2003 | Volume:12 | Issue:4 Page(s): 315-322

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Information Journal Paper

Title

FAST RESPONSIVE THERMOSENSITIVE HYDROGELS AS DRUG DELIVERY SYSTEMS

Author(s)

KHORAM M. | VASHEGHANI FARAAHANI E. | GOLSHAN EBRAHIMI N. | Issue Writer Certificate

Keywords

HYDROGELSQ4

N-ISOPROPYLACRYLAMIDEQ4

FAST RESPONSIVEQ4

DRUG DELIVERYQ4

CALCIUM ALGINATEQ4

Abstract

Ionic and non-ionic temperature sensitive HYDROGELS of poly(N-isopropylacrylamide) and CALCIUM ALGINATE were prepared as interpenetrating networks. CALCIUM ALGINATE was used as a mould to prepare uniform, large size, spherical beads and then extracted to leave a macroporous structure. Swelling behaviour, and drug release kinetics of these thermosensitive HYDROGELS were studied in aqueous media. The swelling observations indicated that equilibrium swelling degree of homopolymer gel increased after extraction of CALCIUM ALGINATE, and also CALCIUM ALGINATE had no effect on lower critical solution temperature (LCST). In addition, equilibrium swelling degree of copolymer HYDROGELS containing Na+, and Ca2+ cations were greater than that of the extracted hydrogel containing only monovalent cations. It was observed that, swelling kinetics of HYDROGELS followed a Fickian behaviour. Drug release experiments indicated that drug release from these HYDROGELS was fast and in Fickian manner.

Cites

HYDROGELS IN CONTROLLED DRUG DELIVERY SYSTEMS

References

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APA: Copy

KHORAM, M., VASHEGHANI FARAAHANI, E., & GOLSHAN EBRAHIMI, N.. (2003). FAST RESPONSIVE THERMOSENSITIVE HYDROGELS AS DRUG DELIVERY SYSTEMS. IRANIAN POLYMER JOURNAL (ENGLISH), 12(4), 315-322. SID. https://sid.ir/paper/85913/en

Vancouver: Copy

KHORAM M., VASHEGHANI FARAAHANI E., GOLSHAN EBRAHIMI N.. FAST RESPONSIVE THERMOSENSITIVE HYDROGELS AS DRUG DELIVERY SYSTEMS. IRANIAN POLYMER JOURNAL (ENGLISH)[Internet]. 2003;12(4):315-322. Available from: https://sid.ir/paper/85913/en

IEEE: Copy

M. KHORAM, E. VASHEGHANI FARAAHANI, and N. GOLSHAN EBRAHIMI, “FAST RESPONSIVE THERMOSENSITIVE HYDROGELS AS DRUG DELIVERY SYSTEMS,” IRANIAN POLYMER JOURNAL (ENGLISH), vol. 12, no. 4, pp. 315–322, 2003, [Online]. Available: https://sid.ir/paper/85913/en

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