THE ROLE OF METRONIDAZOLE ON PREVENTING SIDE EFFECTS OF HIGH DIET FOOD AND DOXYCYCLINE IN RABBITS

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NAJAFZADEH VARZI H.; HAJ HASHEMI V.A.; NAGHDI A.R.

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Journal: SCIENTIFIC-RESEARCH IRANIAN VETERINARY JOURNAL Year:2008 | Volume:4 | Issue:2 (19) Page(s): 81-89

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Title

THE ROLE OF METRONIDAZOLE ON PREVENTING SIDE EFFECTS OF HIGH DIET FOOD AND DOXYCYCLINE IN RABBITS

Author(s)

NAJAFZADEH VARZI H. | HAJ HASHEMI V.A. | NAGHDI A.R. | Issue Writer Certificate

Keywords

METRONIDAZOLEQ2

DOXYCYCLINEQ2

HIGH- FIBRE DIETQ3

RABBITQ2

Abstract

High- fibre food and DOXYCYCLINE can produce gastrointestinal toxic effects and can cause death in RABBITs by changing flora of intestine. In the present study, the role of METRONIDAZOLE on the prevention of these effects was evaluated.Five groups (n=8) of RABBITs were studied for 20 days. Group 1 received usual diet (as control), group 2 received high-fibre diet, group 3 usual diet and DOXYCYCLINE (3 mg/kg-po), group 4 high-fibre diet and METRONIDAZOLE (40mg/kg-po), and group 5 received usual diet, DOXYCYCLINE (3 mg/kg-po) and METRONIDAZOLE (40 mg/kg-po). During this study, any side effect was recorded. In the end of the study, the RABBITs were euthanized by thiopental sodium. Then, intestines and liver were inspected for diarrhea, hemorrhage, ulcer and necrosis studies. Contents of RABBIT intestines were examined for clostridia. Percentages of mortality in groups 2, 3, 4 were 37.5, 62.5, and 25 respectively. Diarrhea was only observed in all RABBITs in group 2. Percentage of intestinal hemorrhage and ulceration in groups 2, 3, 4, and 5 were 87.5, 100, 62.5 and 37.5 respectively. Hepatic necrosis in group 2 and 4 were 12.5% and 37.5% respectively. Clostridium was isolated from feces of RABBITs of groups 2 and 3.The results of the present study are similar to other "relatedstudies. The high-fibre diet and DOXYCYCLINE changed intestinal flora and produced diarrhea and death. Metromidazole could prevent side effects of DOXYCYCLINE better than side effects of high-fibre diet.

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APA: Copy

NAJAFZADEH VARZI, H., HAJ HASHEMI, V.A., & NAGHDI, A.R.. (2008). THE ROLE OF METRONIDAZOLE ON PREVENTING SIDE EFFECTS OF HIGH DIET FOOD AND DOXYCYCLINE IN RABBITS. SCIENTIFIC-RESEARCH IRANIAN VETERINARY JOURNAL, 4(2 (19)), 81-89. SID. https://sid.ir/paper/97121/en

Vancouver: Copy

NAJAFZADEH VARZI H., HAJ HASHEMI V.A., NAGHDI A.R.. THE ROLE OF METRONIDAZOLE ON PREVENTING SIDE EFFECTS OF HIGH DIET FOOD AND DOXYCYCLINE IN RABBITS. SCIENTIFIC-RESEARCH IRANIAN VETERINARY JOURNAL[Internet]. 2008;4(2 (19)):81-89. Available from: https://sid.ir/paper/97121/en

IEEE: Copy

H. NAJAFZADEH VARZI, V.A. HAJ HASHEMI, and A.R. NAGHDI, “THE ROLE OF METRONIDAZOLE ON PREVENTING SIDE EFFECTS OF HIGH DIET FOOD AND DOXYCYCLINE IN RABBITS,” SCIENTIFIC-RESEARCH IRANIAN VETERINARY JOURNAL, vol. 4, no. 2 (19), pp. 81–89, 2008, [Online]. Available: https://sid.ir/paper/97121/en

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