TERATOGENIC AND PATHOLOGIC EFFECTS OF CYCLOSPORINE ON THE KIDNEY OF RAT'S INFANT

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MOHAMMADIAN B.; PA PAHN A.A.; RASHIDI S.H.A.; SISTANI KARAMPOUR N.

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ISSN: 2588-4824

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Journal: SCIENTIFIC-RESEARCH IRANIAN VETERINARY JOURNAL Year:2006 | Volume:2 | Issue:2 (13) Page(s): 5-11

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Title

TERATOGENIC AND PATHOLOGIC EFFECTS OF CYCLOSPORINE ON THE KIDNEY OF RAT'S INFANT

Author(s)

MOHAMMADIAN B. | PA PAHN A.A. | RASHIDI S.H.A. | SISTANI KARAMPOUR N. | Issue Writer Certificate

Keywords

CYCLOSPORINEQ3

INFANTQ2

TERATOGENICQ3

KIDNEYQ2

RATQ2

Abstract

CYCLOSPORINE is a potent immunosuppressive agent used to prolong the survival of allogenic transplants. Transplant patients who become pregnant require continued immunosuppression. Therefore this study intends to investigate the TERATOGENIC and pattological effects of CYCLOSPORINE on KIDNEYs of RAT INFANTs. Fifty RATs of N- Mari strain (40 female and 10 male) were kept under the same condition. The RATs were divided into four groups (10 female and 2 male). After mating, observation of vaginal plug in the female RATs was carried out on the first day of pregnancy. Then, CYCLOSPORINE was administered to 3 groups of pregnant RATs in accordance with their embryo's development stageie (predifferentiation, embryonic, fetal), with a dosage of 50 mg/kg/day of body weight per day. The control group of pregnant RATs did not receive drugs during pregnancy. The second, third and fourth groups of pregnant RATs were treated with in the first, second and third weeks of pregnancy respectively. INFANTs of each group were counted and kept in special cages. The statistical assessment of survived embryos shows the significant difference between the control group and testing ones (P<0.05). The differences between the second and third group as well as the second and fourth group were also significant (P<0.05). However, the difference between the third and fourth group (P>0.05) was not significant. The newborns of all groups were stopped taking milk at 3 weeks of age. At this stage, they were anaesthetized and samples were taken from their KIDNEYs. In macroscopical investigation were not difference between the control and the treated ones. Pathological studies showed that in each embryo developmental stage CYCLOSPORINE had caused coagulative necrosis and cell swelling of renal tubules as well as prolifiration of visceral layer of bowman's capsule. However, no lesion were seen in KIDNEY of the RAT INFANTs in the control group.

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References

THE EFFECTS OF CYCLOSPORINE ON PREGNANCY OUTCOME: THE NUMBER ANDMORTALITY OF MICE EMBRYOS

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APA: Copy

MOHAMMADIAN, B., PA PAHN, A.A., RASHIDI, S.H.A., & SISTANI KARAMPOUR, N.. (2006). TERATOGENIC AND PATHOLOGIC EFFECTS OF CYCLOSPORINE ON THE KIDNEY OF RAT'S INFANT. SCIENTIFIC-RESEARCH IRANIAN VETERINARY JOURNAL, 2(2 (13)), 5-11. SID. https://sid.ir/paper/97324/en

Vancouver: Copy

MOHAMMADIAN B., PA PAHN A.A., RASHIDI S.H.A., SISTANI KARAMPOUR N.. TERATOGENIC AND PATHOLOGIC EFFECTS OF CYCLOSPORINE ON THE KIDNEY OF RAT'S INFANT. SCIENTIFIC-RESEARCH IRANIAN VETERINARY JOURNAL[Internet]. 2006;2(2 (13)):5-11. Available from: https://sid.ir/paper/97324/en

IEEE: Copy

B. MOHAMMADIAN, A.A. PA PAHN, S.H.A. RASHIDI, and N. SISTANI KARAMPOUR, “TERATOGENIC AND PATHOLOGIC EFFECTS OF CYCLOSPORINE ON THE KIDNEY OF RAT'S INFANT,” SCIENTIFIC-RESEARCH IRANIAN VETERINARY JOURNAL, vol. 2, no. 2 (13), pp. 5–11, 2006, [Online]. Available: https://sid.ir/paper/97324/en

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