EFFECT OF LEVAMISOLE ADMINISTRATION ON HUMORAL IMMUNE RESPONSE AGAINST INFLUENZA VACCINE IN BROILER CHICKENS

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MAYAHI M.; SEYFIABAD SHAPOURI M.R.; TALAZADEH F.

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Journal: SCIENTIFIC-RESEARCH IRANIAN VETERINARY JOURNAL Year:2007 | Volume:3 | Issue:1 (14) Page(s): 89-94

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Title

EFFECT OF LEVAMISOLE ADMINISTRATION ON HUMORAL IMMUNE RESPONSE AGAINST INFLUENZA VACCINE IN BROILER CHICKENS

Author(s)

MAYAHI M. | SEYFIABAD SHAPOURI M.R. | TALAZADEH F. | Issue Writer Certificate

Keywords

LEVAMISOLEQ2

IMMUNE RESPONSEQ2

KILLED VACCINE INFLUENZAQ3

BROILER CHICKENSQ3

Abstract

The killed avian influenza vaccines is recommended for preventing avian influenza disease subtype H9N2. However, the available vaccines don't produce high levels of antibody unfortunately. Considering a direct relationship between the antibody titer and protection against this disease, this study is investigating the effect of an immunostimulant drug "LEVAMISOLE" on production of antibody against killed influenza vaccine subtype H9N2.Therefore, 100 day-old chickens were procured and divided into 5 groups of A, B, C, D and E. Two days before vaccination, chickens of group A and B received a daily dose of 2mg LEVAMISOLE (4mg totally) orally and intraperitonealy respectively. Chickens of group C and D received influenza vaccine and 4mg LEVAMISOLE simultaneously, and with same routes.Group E (Control group) was vaccinated against influenza disease but didn't receive LEVAMISOLE. On the ninth day, chickens of each group were vaccinated once with killed avian influenza vaccine back neck subcutaneously. On days 0, 7, 21 and 35 of post vaccination, 10 chickens of each group were bled randomly, and influenza antibody titers were determined by HI test. The results showed that daily administration of 2mg LEVAMISOLE from two days before vaccination, or 4 mg LEVAMISOLE at the time of vaccination against influenza disease increased avian influenza antibody titer. There were not seemang differences between oral or intraperitoneal LEVAMISOLE administration on the specific avian influenza antibody titer.

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APA: Copy

MAYAHI, M., SEYFIABAD SHAPOURI, M.R., & TALAZADEH, F.. (2007). EFFECT OF LEVAMISOLE ADMINISTRATION ON HUMORAL IMMUNE RESPONSE AGAINST INFLUENZA VACCINE IN BROILER CHICKENS. SCIENTIFIC-RESEARCH IRANIAN VETERINARY JOURNAL, 3(1 (14)), 89-94. SID. https://sid.ir/paper/97483/en

Vancouver: Copy

MAYAHI M., SEYFIABAD SHAPOURI M.R., TALAZADEH F.. EFFECT OF LEVAMISOLE ADMINISTRATION ON HUMORAL IMMUNE RESPONSE AGAINST INFLUENZA VACCINE IN BROILER CHICKENS. SCIENTIFIC-RESEARCH IRANIAN VETERINARY JOURNAL[Internet]. 2007;3(1 (14)):89-94. Available from: https://sid.ir/paper/97483/en

IEEE: Copy

M. MAYAHI, M.R. SEYFIABAD SHAPOURI, and F. TALAZADEH, “EFFECT OF LEVAMISOLE ADMINISTRATION ON HUMORAL IMMUNE RESPONSE AGAINST INFLUENZA VACCINE IN BROILER CHICKENS,” SCIENTIFIC-RESEARCH IRANIAN VETERINARY JOURNAL, vol. 3, no. 1 (14), pp. 89–94, 2007, [Online]. Available: https://sid.ir/paper/97483/en

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