The study of the higher education policies for university entrepreneurship ecosystem creation has become one of the major new and important topics in the field of higher education and university entrepreneurship ecosystems. Hence, changing the approach from purely educational and research planning to the establishment of the university campus entrepreneurship ecosystem has been attended by the world's leading universities. Current paper aims to design a model for creating an Entrepreneurial University Campus Ecosystem (EUCE) with the configuration and leveling of the factors. Hence using a qualitative approach, an in-depth and exploratory interview was conducted with 20 experts from the research population. Then, using open and axial coding method, 9 axial factors were identified. The axial factors affecting the creation of Entrepreneurial University Campus Ecosystem (EUCE) have been classified using an Interpretive Structural method. A questionnaire was designed and distributed among 28 academic and field experts. A group of five experts on EUCE has studied the completed questionnaires and determined the relations between subject to disagreement components. Then, Interpretive Structural Modelling was built using Matlab software to develop an EUCE model.