Deviational approach in interpretation of Quranic verses has a long history, and goes back even to the early decades of appearance of Islam. Such interpretations and commentaries disturb the order of Quranic words reasoning, and propagates error and mislead instead of Quran guide.From a methodological view, some factors of this approachhave been reckoned, which refers to Quran itself, and the characteristics of the interpretors, and their commentary methods.The opponents of Quran, some groups such as the extremists, Ismailities,... gnostics, Sufis, and the Orientalists have provided some of the deviational, and misleading interpretations in their works.