MULTICOMPONENT REACTIONS ARE PERFORMED WITHOUT NEED TO ISOLATE ANY INTERMEDIATE DURING THE REACTION, WHICHREDUCE THE AMOUNT OF TIME AND ENERGY USED [1]. THERE HAS BEEN TREMENDOUS DEVELOPMENT IN THREE OR FOUR COMPONENT REACTIONS. BISCOUMARIN DERIVATIVES HAVE BEEN ATTRACTED CONSIDERABLE INTEREST BECAUSE OF THEIR BIOLOGICAL AND PHARMACOLOGICAL ACTIVITIES [23]. ...

COUMARIN AND ITS DERIVATIVES ARE KNOWN TO POSSESS A WIDE RANGE OF BIOLOGICAL ACTIVITIES INCLUDING ANTI-HIV, ANTI-BIOTIC, ANTI-FUNGAL, ANTI-BACTERIAL, ANTI-OXIDANT, ANTI-CANCER, AND ANTI-COAGULANT [1-4]. AMONG VARIOUS DERIVATIVES OF COUMARIN, BISCOUMARINS HAVE AROUSED CONSIDERABLE INTEREST. THEY ARE USUALLY PREPARED FROM THE REACTION OF ALDEHYDES WITH TWO EQUIVALENTS OF 4-HYDROXYCOUMARIN IN THE PRESENCE OF A CATALYST.

BISCOUMARINS AND DIHYDROPYRANO [C] CHROMENES ARE OF CONSIDERABLE INTEREST DUE TO THEIR WIDESPREAD BIOLOGICAL PROPERTIES [1–3]. A NUMBER OF METHODS HAVE BEEN REPORTED FOR THE SYNTHESIS OF BISCOUMARINS [4–6]. ...

AN EFFICIENT ONE POT APPROACH FOR THE SYNTHESIS OF DIHYDROPYRANO [3, 2-C] CHROMENESANDBISCOUMARINS AS IMPORTANT HETEROCYCLIC COMPOUNDS WITH PHARMACOLOGICAL AND BIOLOGICAL PROPERTIES HAVE BEEN PREPARED USING NANOCRYSTALLINE MAGNESIUM OXIDE. MAGNESIUM OXIDE NANOPARTICLES WERE SIGNIFICANTLY CATALYZED THREE COMPONENT REACTION OF ALDEHYDES, ETHYLCYANOACETAT AND 4-HYDROXYCOUMARIN IN HIGH YIELDS AND SHORT REACTION TIMES UNDER SOLVENT-FREE CONDITIONS. NANO MAGNESIUM OXIDE AS AN EFFICIENT, AVAILABLE AND CHEAP HETEROGENEOUS NANOPARTICLES WERE USED FOR SEVERAL TIMES IN THE SYNTHESIS OF DIHYDROPYRANO [3, 2-C] CHROMENES AND BISCOUMARINS.

UMARINS PLAY AN IMPORTANT ROLE IN BOTH NATURAL AND SYNTHETIC ORGANIC CHEMISTRY BECAUSE OF THEIR POTENTIAL APPLICATIONS IN FRAGRANCE, PHARMACEUTICAL AND AGROCHEMICAL INDUSTRIES [1].BISCOUMARINS ARE GENERALLY SYNTHESIZED BY COMBINATION. ...

COUMARINS AND THEIR DERIVATIVES EXHIBIT PHARMACOLOGICAL PROPERTIES SUCH AS ANTIBACTERIAL, ANTIFUNGAL, PHARMACOLOGICAL, ANTI-CANCER AND ANTICOAGULANT ACTIVITY. BISCOUMARINS DERIVATIVES ARE EFFECTIVE UREASE INHIBITORS. ALSO, A NUMBER OF COUMARIN DERIVATIVES WERE SHOWN HIV INHIBITORY ACTIVITY….

BISCOUMARINS DERIVATIVES ARE THE MEMBERS OF AN IMPORTANT GROUP OF ORGANIC COMPOUNDS THAT EXHIBIT BIOLOGICAL ACTIVITIES SUCH AS ANTIBACTERIAL, ANTIFUNGAL, PHARMACOLOGICAL, ANTI-CANCER, ANTICOAGULANT, INSECTICIDAL, ANTIHELMINTHIC, HYPNOTIC, AND HIV PROTEASE INHIBITION [1]. A NUMBER OF...