When evaluating mammograms, one looks for masses, areas of asymmetry or architectural distortion and microcalcifications.Calcification found on screening and diagnostic mammography may be typically benign, of intermediate type, or have a high probability of malignancy.The calcifications that most radiologists have prob-lems dealing with are those of "intermediate con-cern."Occasionally spot compression-magnification views are necessary to evaluate and analyze the calcification characteristics.The morphology and distribution of calcifications are often clues to the differential diagnosis and appropriate management. Calcifications deserve closer scrutiny than those in a regional or diffuse distribution.In this article, we discuss the imaging evaluation and management of lesions found on screening and diagnostic mammography, with the focus on commonly encumbered questions and problems. We will also present our interesting cases with breast calcification.