Introduction: COVID-19 infection can be complicated by coagulation derangement and a high risk of thromboembolic episodes. Our study aimed to investigate coagulation parameters in COVID-19 patients and their correlation with clinical severity. Methods: We analyzed coagulation parameters PT, APTT, D-Dimer, and Fibrinogen in 98 RT-PCR-confirmed COVID-19 patients admitted to the Government Institute of Medical Sciences, Gautam Buddha Nagar, Uttar Pradesh, India. Results: This study involved 69 males (70. 50%), and 29 (29. 5%) were females. The mortality rate was 6. 12% (n= 06). Forty-six patients (46. 94%) had comorbidities. Thirty-four patients had elevated PT, and 7 had high APTT, whereas D-dimer and fibrinogen levels were raised in 68 and 61 patients, respectively. Among all four parameters, D-Dimer levels were significantly associated with disease severity. Conclusion: Derangement of Ddimer levels is significantly associated with disease severity in COVID-19 infection.

Background and purpose: Ferritin and D-dimer, as biomarkers of inflammation and coagulation disorders, respectively, play an important role in assessing the severity of COVID-19. The aim of this study was to investigate the relationship between these two markers and patients’ demographic, biochemical, hematological, and inflammatory characteristics in COVID-19. Materials and methods: In this retrospective cross-sectional (record-based) study, all patients with confirmed COVID-19 who were hospitalized at Bu Ali Sina Hospital, Sari, between March 2020 and January 2021 were screened. After applying the inclusion and exclusion criteria, a total of 795 patients (442 women and 353 men) were included in the final analysis. Data on ferritin, D-dimer, urea, creatinine, blood glucose, liver enzymes, bilirubin, electrolytes, ESR, CBC, CRP, and coagulation parameters (PT, INR, PTT) were extracted from patient records. Results: Ferritin and D-dimer concentrations were significantly higher in women than in men (P<0. 001 and P=0. 025, respectively). Both markers were significantly elevated in patients with high CRP levels (P<0. 001). Ferritin exhibited a positive and significant correlation with inflammatory indices (WBC, neutrophils, ESR), liver enzymes, and renal parameters (urea and creatinine). D-dimer also showed a positive correlation with coagulation indices (INR, PT, PTT), liver enzymes, and renal parameters, and a negative correlation with hemoglobin (Hb), hematocrit (Hct), and mean corpuscular hemoglobin (MCH). In multiple regression analysis, CRP, ALP, and LDH were independently associated with increased ferritin levels, whereas elevated D-dimer was significantly associated with increased CRP, INR, white blood cell count, and phosphorus levels. Conclusion: Continuous monitoring of ferritin and D-dimer in COVID-19 patients may improve clinical outcomes by guiding the management of inflammation and coagulation-related risks.

Background and purpose: The SARS-CoV-2 can increase blood levels of D-dimer by causing thrombosis and affecting the homeostasis system. This study aimed at investigating the blood levels of DDimer and its relationship with the incidence of headache in patients with type 2 diabetes infected with COVID-19 who were admitted to Ilam Shahid Mostafa Hospital, Iran. Materials and methods: We studied the patients hospitalized in Ilam Shahid Mostafa Hospital. with COVID-19 (n=988) in two groups of with and without diabetes. Blood levels of D-dimer, and glucose, and also the incidence of headache were evaluated in all patients. Results: Fasting blood sugar levels, blood levels of D-dimer, white blood cell count, and ESR significantly increased in diabetic patients with COVID-19 compared with the non-diabetic patients (P<0. 001). The incidence of headache was found to be significantly lower in diabetic patients than non-diabetic patients (n= 91, P= 0. 0009). Conclusion: According to present research, there is an inverse relationship between the blood levels of D-dimer and incidence of headache in diabetic people with COVID-19, as by increase in blood levels of Ddimer the incidence of headache decreased.

Corona virus 2019 (COVID-19) is a public health emergency and according to the recent statistic of World Health Organization (WHO), this novel virus has infected all continents. During this outbreak, there is an urgent need for documentation of laboratory predictors to discriminate between mild and severe forms of this virus. In this pandemic, prompt identification of clinical and laboratory prognostic factors of progression towards critical and lethal forms of this disease is mandatory. During this new infection, lymphopenia, thrombocytopenia, sometimes neutrophilia, elevation of Ddimer, prolongation of prothrombin time (PT), and Partial Thromboplastin Time (PTT), and also increased level of fibrin degradation products (FDP) could occur. Moreover, elevation of erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), procalcitonin, ferritin, Lactate dehydrogenase (LDH), and interleukin-6 (IL-6) are other laboratory features. These parameters will enable risk stratification and favorable allocation of limited and technical resources particularly in under developed countries. In this review article, alteration of hematologic laboratory findings has been discussed.

Background: Tuberculosis (TB) is an infectious disease caused by mycobacterium tuberculosis (Mtb). This infection causes the release of proinflammatory cytokines that affect hemostasis. Pulmonary TB infection causes an increased activation of procoagulant factors, decreased anticoagulant factors and suppresses fibrinolysis which causes hypercoagulable. Our study is conducted to assess the association between pulmonary TB infection (PTB) with hemostatic parameters before and after intensive phase treatment. Methods: This was an analytic observational prospective cohort design. The study was conducted at the Community Center for Lung Health in South Sulawesi. Studied subjects were recruited by consecutive sampling, in which the patients who met the inclusion criteria received intensive phase of ATD treatment. PT, aPTT, fibrinogen, and D-dimer were measured before treatment and after the intensive phase of ATD. These data were analyzed using the SPSS Version 22. Results: In this study, 30 subjects are new cases of PTB. Prothrombin time, aPTT and Ddimer levels were higher in far advanced lesions and smear-positive sputum group (p<0. 001). There was a significant level decrease in PT, aPTT, fibrinogen, D-dimer after intensive phase treatment (p<0. 001). Conclusion: Pulmonary tuberculosis infection is associated with hypercoagulability which is characterized by an increase in hemostatic parameters and has significant improvement after intensive phase of ATD treatment.