The monitoring and analyzing of drought conditions is one of the main requirements for water resources management. In present paper, Standard Precipitation Index (SPI) and Standardized Precipitation Evapotranspiration Index (SPEI) were compared in order to assess the drought conditions in the Esfarayen-Sabzevar region. As in the aforementioned region sufficient long-term data is not available to assess the drought, reanalysis data of ERA-INTERIM were used to be combined with the observed data. For this purpose, climatic data of precipitation and temperature were extracted for each station in the statistical period of 1979-2016 using the web interfaces, Python script, ECMWF WebAPI and ArcGIS software. After correcting the bias of the data based on observational data, combined data of precipitation and temperature were obtained for the aforementioned period and used as the basis for calculating the drought. Finally, drought assessment and estimating the correlation of SPI and SPEI were conducted for three stations of Sarcheshme, Ghasemabad, and Jaghtay in the time scales of 3, 6, 12, 18, and 24 months. After generating data combination, the Root Mean Square Error (RMSE) and Bias were decreased from 0. 39 and 6. 69 to 0. 32 and 0. 24 respectively. Thus similar approach to data can be used for drought assessment in areas with lack of observed data. Results showed that in the short-term scales the frequency of dry and wet periods is high. By increasing the time scale, the frequency of the dry and wet period decreases but their duration increases. In most cases in the stations both indices showed coordination in the dry and wet periods. Based on the provided results regarding the correlation between SPI and SPEI indices, there is a positive and significant correlation between the above indices and the correlation is higher in the humid regions. As a result, the SPI index can be used in the regions with no temperature data with a precession similar to the SPEI index.