Pumped storage reservoirs are one of the newest systems in saving electricity. According to importance of convey water for placed the turbine and knowing that, almost of instability of underground area is for ignorance in some engineering geology parameters, we have decided to investigate this parameters. In this research we have been studied the engineering geology parameters along tunnel, changing in some of these parameters are shown in Rockwork 2008. After all with the new classification called IRMR the engineering geology parameters of rock mass have been studied, compare the result with classic classification, RMR and GSI shown that the outlet and entrance of tunnel are under bad situation. At the next, studied of joint for recognized the wedge base on finite element method have been investigate. Eventually with emphasis on rock bursting, squeezing and geomechanic studied the admissible advancement step for two section of tunnel base on FLAC 3D have been carried out. Using such studied make safety in services and reduce the spent-time.

Objective (s): This study investigated the effects of melatonin, famotidine, mirtazapine, and thiamine pyrophosphate on ischemia/reperfusion (I/R) injury in diabetic rats and evaluated oxidant and antioxidant marker measurement results. It also examined the effects of the drugs aimed at preventing infertility that may result from I/R injury.Materials and Methods: Diabetic rats were divided into a control group (IRC) to be exposed to I/R, an ovarian I/R+2.2 mg/kg melatonin (IRML) group, an ovarian I/R+famotidine (IRFA) group, an ovarian I/R+20 mg/kg mirtazapine (IRMR) group, an ovarian I/R+20 mg/kg thiamine pyrophosphate (IRTP) group, and a sham operation (SO) group.Results: In the control group exposed to I/R, the levels of the oxidant parameters Malondialdehyde (MDA) and Myeloperoxidase (MPO) were significantly higher compared with the SO group, while the levels of the antioxidant parameters glutathione (GSH), Glutathione peroxidase (GPO), Glutathione reductase (GSHRd), Glutathione S- transferase (GST), and Superoxide dismutase (SOD) were significantly lower. Melatonin, famotidine, mirtazapine, and thiamin pyrophosphate prevented a rise in oxidant parameters and a decrease in antioxidants in ovarian tissue exposed to I/R. However, apart from thiamin pyrophosphate, none of the drugs were able to prevent infertility caused by I/R injury.Conclusion: Prevention of ovarian I/R injury-related infertility in rats with induced diabetes is not through antioxidant activity. Thiamine pyrophosphate prevents infertility through an as yet unknown mechanism. This study suggests that thiamine pyrophosphate may be useful in the prevention of I/R-related infertility in diabetics.