The knowledge about treatment of insect stings is very important for medical staffs. They need to know how they should manage and treat the insect stings in emergency status. Because of these reason we have written a review article about insect stings to provide a brief but complete aspects of stings management for medical staffs.Insects include vespids, apids and fire ants. The venom is delivered by the ovipositor (stinger) attached to the abdomen of the insect. Venoms are highly complex and include biogenic amines, polypeptides and enzymes. Manifestations of hymenoptera stings can be divided into three categories: Local reactions, toxic reactions and allergic (hypersensitivity) reactions.Toxicity varies with amount of venom injected, patient sensitivity, age of patient and site of sting. Clinical effects include ocular, Ingestion and topical.Ocular: Flush eyes with a gentle stream of tepid water for 5 minutes.Topical: Immediately remove stinger if present, wash area with soap and water. Application of a 20% solution of an aluminum salt to sting site Follow with application of ice pack. Baking soda or calamine lotion my provide relief for some patients. If the sting is on an extremity, apply a firm crepe bandage as much of the limb as possible. In serious cases, patients should be referred to a health care facility. Allergic reactions: Ventilation, Epinephrine, Diphenhydramine by injection, Glucagon, Ranitidine or cimetidine, for persistent hypotention corticosteroids, nebulized salbutamol, Dopamin and tetanus prophylaxis if necessary.Toxic reactions: Symptomatic and supportive therapy.Delayed serum sickness reaction: may require antihistamines and corticosteroids.