Background: Urban liveability is a multidimensional concept associated with many domains of human health. Objectives: This study aimed at investigating the association between urban liveability and cancer incidence in Iran. Methods: The data of provincial-level urban liveability were obtained from reliable sources. The data of cancer incidence were inquired from the population-based cancer registry of the Iranian Ministry of Health and Medical Education in 2016. Urban liveability scores were determined in all provinces of Iran by utilizing the global liveable city index (GLCI) method. Negative binomial Poisson regression was used to examine the relationship between urban liveability and cancer incidence. Results: Provinces with a higher urban liveability had a higher likelihood of cancer incidence. Higher economic score was significantly associated with higher incidence in colorectal (IRR = 1. 49, P = 0. 005), liver (IRR = 1. 48, P = 0. 002), leukemia (IRR = 1. 39, P = 0. 005), lung (IRR = 1. 39, P = 0. 039), breast (IRR = 1. 38, P = 0. 011), and prostate cancers (IRR = 2. 11, P < 0. 001). Also, provinces with higher environmental friendliness and sustainability had signifi cantly more stomach (IRR = 1. 53, P = 0. 004), colorectal (1. 79, P < 0. 001), lung (IRR = 1. 43, P = 0. 014), and prostate (IRR = 1. 50, P = 0. 032) cancer incidence. Provinces with higher political governance had signifi cantly more breast cancer (IRR = 1. 34, P = 0. 002) and leukemia (IRR = 1. 30, P = 0. 016) incidence rates. Conclusions: Along with the development of urban liveability, the incidence of cancers is increasing in Iran. Cancer control strategies should be implemented especially in settings with higher urbanization.