Introduction: POSTOPERATIVE nausea and vomiting (PONV) is a major unpleasant symptom in the POSTOPERATIVE period that has many causes, including the choice of anaesthetic drugs and induction. The prevention of PONV is considered as equally important as the prevention of POSTOPERATIVE pain. Thus, this study was performed to evaluate and compare the prevalence of  PONV after abdominal hysterectomy  using general anesthesia. To this end, the roles of two different drugs regimens, Propofol and Tiopental Sodium, were studied.Materials and Methods: This single-blinded clinical research study was carried out in Ariya Hospital during the years of 1387 and 1388 (H.S.). For this study, 104 ASA class I or II women, aged 30-60 years, were scheduled for abdominal hysterectomy by the same surgeon The operations lasted about 25 to30 minutes. The samples of the study were randomized into one of two groups: Group P (n=52) who received the induction of 2 mg/kg Propofol with the maintenance of 5 mg/kg/hr of Propofol. On the other hand, group T (n=52) were given the indution of 5 mg/kg Tiopental Sodium with the maintenance of 0.5 MAC Halothane. All the patients received 4 mg/kg Fentanyl, 0.6 mg/kg Atracurium and the ventilation was controled at O2/N2O 50/50. The number of patients suffering from nausea and/or vomiting at the recovery room was recorded within 6 and 24 hours after the operation. The data were then statistically analyzed using Chi-square and Fisher’s exact test.Results: After the operations, the number of patients experiencing nausea at the recovery room was %5.8 (n=3) for group P and %59.6 (n=31) for group T (P=0.001). %5.8 (n=3) of the patients in group P were vomiting while %28.8 (n=15) in group T (P=0.003) had that experience. The number of patients experiencing nausea within 6 hours after the operation was %55.8 (n=29) for group P and %67.3 (n=35) for group T (P=0.314). In terms of vomiting in 6 hours of postoperation, %21.2 (n=11) of the patients in group P and %38.5 (n=20) in group T were having the experience (P=0.085). Also, the results indicate that the number of patients experiencing nausea within 24 hours of postoperation was %3.8 (n=2) for group P and %32.7 (n=17) for group T (P=0.001). However, %1.9 (n=1) of the patients in group P and %5.8 (n=3) in group T (P=0.618) were suffering from vomiting within the same duration of time. As a whole, the findings indicate that the incidences of nausea and vomiting at the recovery room were significantly lower in group P than in group T, but the difference in 6 hours after operation was insignificant. Also, the prevelance of nausea in 24 hours after operation was significantly lower in group P than in group T, but the difference in terms of vomiting within the same period was insignificant.Conclusion: For women undergoing abdominal hysterectomy, the choice of induction and maintenance of general anesthesia with Propofol provides a better prophylaxis against PONV than the induction with Thiopental Sodium with the maintenance of Halothane.

Background: Gabapentin is an anticonvulsant that has POSTOPERATIVE analgesic effects but there are limited studies on its POSTOPERATIVE administration.Objectives: The present study was conducted to evaluate the effect of the POSTOPERATIVE oral gabapentin on pain and morphine consumption.Patients and Methods: In a double blind, randomized study, 64 patients undergoing internal fixation of tibia under spinal anesthesia were randomly assigned to receive oral gabapentin or placebo immediately after the surgery. Pain scores were recorded at time points of 2, 12 and 24 hours POSTOPERATIVEly using visual analog scale (VAS). Time duration from the end of surgery until morphine administration and total morphine requirement in the first 24 hours were recorded.Results: The estimated duration of surgeries was 120-150 minutes. VAS score was not significantly different between the two groups at 2, 12 and 24 hours after surgery. There was no significant morphine consumption difference between the groups.Conclusions: Our study showed no significant analgesic efficacy of oral gabapentin 300 mg immediately after tibia internal fixation surgery under spinal anesthesia at time points of 2, 12 and 24 hours POSTOPERATIVEly.

The practice of modern anesthesiology has been developed from intraoperative period into perioperative period. POSTOPERATIVE pain management is one of the most important components of adequate post-surgical patients care. This article wrote with the aim of emphasis on importance and effectiveness of post-operative pain management. Reading this article is beneficial for physicians, interventional pain managers and who care about pain medicine. Unrelieved acute pain after surgery usually elicits pathophysiologic neural alterations, including not only peripheral but also central sensitization which evolves into chronic pain syndromes. The main purpose of perioperative pain control is providing an adequate comfort level and acceptable side effects for patients. Effective POSTOPERATIVE analgesia improves patients’ outcome as observed by early ambulation, decrease in side effects, and reduce the incidence of POSTOPERATIVE chronic pain (1-3).

Pain has many adverse effects on all organ systems and its role is more important in POSTOPERATIVE conditions. Use of opioids for pain management results in various complications. Magnesium sulfate may play a role in POSTOPERATIVE pain management and reduce the opioid-consumption trend. We assessed this effect of magnesium sulfate. In a double blind randomized clinical trial 54 male patients in ASA class I undergoing general anesthesia for elective unilateral inguinal herniorrhaphy were randomly allocated in two equal groups who received 15mL of 20% magnesium sulfate (cases) or 15 mL saline (controls) intravenously after anesthesia induction. Surgical team and anesthetic protocol were identical. We measured POSTOPERATIVEly the intensity of pain [according to visual analog pain score(VAS)] in the first, 6th. 12th,and 24th hour after surgery and pethidine administration (that was prescribed on demand) during one day after surgery. Cases showed less pain intensity in the 6th h (p=0.026), 12th h (p<0.001) and 24thh (p=0.028) postop and received less pethidine (p=0.027). Side effects were statistically identical. In conclusion, administration of intravenous magnesium sulfate is associated with less pain and fewer analgesic requirements without any increase in side effects. Magnesium sulfate could be an interesting adjuvant for POSTOPERATIVE analgesia.