Poorly soluble drugs are often a challenging problem in drug formulation. Midazolam is considered one of the best first-line drugs in managing status epilepticus in children who require emergency drug treatment. Owing to poor water solubility, however, oral bioavailability of midazolam is relatively low and insufficient. To improve its dissolution and absorption, nanosuspensions of midazolam hydrochloride were formulated with different Stabilizers, such as Tween 80, Poloxamer 188, sodium carboxy methyl cellulose (NaCMC) and three-methyl chitosan (TMC) using the ultrasonic technique. The effects of combined Stabilizers on nanosuspension physical properties such as particle size, zeta potential, viscosity and drug solubility were evaluated. The optimum midazolam nanosuspension containing 0. 3% Poloxamer 188 and 0. 3% TMC W/W had a mean particle size of 269 , ±,  , 4 nm, zeta potential of 28. 3 , ±,  , 4 mV, viscosity of 23 MPa s and solubility of 398 μ, g/mL. The freeze-dried powder of desirable midazolam nanosuspension was characterized by particle-size analyzer, SEM, stability test and dissolution test. Drug dissolution of the optimum midazolam nanosuspension was 1. 8 times higher than that of the midazolam coarse suspension. The stability test showed that the midazolam nanosuspension was stable for 3 months. All results indicated that the nanosuspension of midazolam has proper properties for a new drug dosage form of midazolam with high oral bioavailability.

This paper describes the design of robust power system Stabilizers (PSS) for a single generator tie line (SGTL) power system. Unlike the conventional PSS design based on a single system operating point, the proposed method develops a more realistic approach by taking into account various uncertainties involved in power system operation and modelling such as disturbances, modelling errors, changes in the system parameters, system structure and operating conditions. This approach provides a technique for determining stabilizer transfer function for a region of power system operating points establishing a demarcation line between stable and unstable areas on the complex power plane. The Nevanlinna-Pick theory is applied to obtain the final transfer function. The design procedure is demonstrated for a system with typical parameters. Extensive simulation results are presented to confirm the superiority of the proposed PSS in comparison with a conventional PSS.

In this paper, we use the left(right) Stabilizers of a BCKalgebra (X, *, 0) and produce two basis for two different topologies. Then we show that the generated topological spaces by these basis are Bair, connected, locally connected and separable. Also we study the other properties of these topological spaces.