Effect of combined stabilizers on midazolam nanosuspension properties

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Soroushnia Arezou; GANJI FARIBA; VASHEGHANI FARAHANI EBRAHIM; MOBEDI HAMID

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Journal Paper

Paper Information

Journal: Iranian Polymer Journal Year:2022 | Volume:31 | Issue:2 Page(s): 215-222

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Title

Effect of combined stabilizers on midazolam nanosuspension properties

Author(s)

Soroushnia Arezou | GANJI FARIBA | VASHEGHANI FARAHANI EBRAHIM | MOBEDI HAMID

Keywords

Stabilizer

Midazolam

Nanosuspension

Polymer

Surfactant

Characterization

Abstract

Poorly soluble drugs are often a challenging problem in drug formulation. Midazolam is considered one of the best first-line drugs in managing status epilepticus in children who require emergency drug treatment. Owing to poor water solubility, however, oral bioavailability of Midazolam is relatively low and insufficient. To improve its dissolution and absorption, Nanosuspensions of Midazolam hydrochloride were formulated with different Stabilizers, such as Tween 80, Poloxamer 188, sodium carboxy methyl cellulose (NaCMC) and three-methyl chitosan (TMC) using the ultrasonic technique. The effects of combined Stabilizers on Nanosuspension physical properties such as particle size, zeta potential, viscosity and drug solubility were evaluated. The optimum Midazolam Nanosuspension containing 0. 3% Poloxamer 188 and 0. 3% TMC W/W had a mean particle size of 269 , ±, , 4 nm, zeta potential of 28. 3 , ±, , 4 mV, viscosity of 23 MPa s and solubility of 398 μ, g/mL. The freeze-dried powder of desirable Midazolam Nanosuspension was characterized by particle-size analyzer, SEM, stability test and dissolution test. Drug dissolution of the optimum Midazolam Nanosuspension was 1. 8 times higher than that of the Midazolam coarse suspension. The stability test showed that the Midazolam Nanosuspension was stable for 3 months. All results indicated that the Nanosuspension of Midazolam has proper properties for a new drug dosage form of Midazolam with high oral bioavailability.

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APA: Copy

Soroushnia, Arezou, GANJI, FARIBA, VASHEGHANI FARAHANI, EBRAHIM, & MOBEDI, HAMID. (2022). Effect of combined stabilizers on midazolam nanosuspension properties. IRANIAN POLYMER JOURNAL (ENGLISH), 31(2), 215-222. SID. https://sid.ir/paper/1040414/en

Vancouver: Copy

Soroushnia Arezou, GANJI FARIBA, VASHEGHANI FARAHANI EBRAHIM, MOBEDI HAMID. Effect of combined stabilizers on midazolam nanosuspension properties. IRANIAN POLYMER JOURNAL (ENGLISH)[Internet]. 2022;31(2):215-222. Available from: https://sid.ir/paper/1040414/en

IEEE: Copy

Arezou Soroushnia, FARIBA GANJI, EBRAHIM VASHEGHANI FARAHANI, and HAMID MOBEDI, “Effect of combined stabilizers on midazolam nanosuspension properties,” IRANIAN POLYMER JOURNAL (ENGLISH), vol. 31, no. 2, pp. 215–222, 2022, [Online]. Available: https://sid.ir/paper/1040414/en

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