Cutaneous leiomyosarcoma is a rare soft tissue neoplasm of smooth muscle derivation which subdivided into cutaneous and subcutaneous form. The majority of former type occurs on the hair bearing surfaces of the extremities, particularly the lower extremities.We present a rare case of cutaneous leiomyosarcoma occurred on the scalp of a 64 years old man with history of previous trauma (multiple burning due to his work, bakery). The Masson-trichrome and mc stains for vimentin, desmin, alpha 1-antitrypsin, and Smooth Muscle Antibody (SMA)were positive and cytokeratin and S-100 were negative. The case was a primary scalp leiomyosarcoma in which other spindle cell sarcomas and carcinomas were excluded.

Primary intracranial leiomyosarcomas are rare tumors that arise from the mesenchymal cells of the dura mater or cerebral blood vessels Here we report the case of an extra axial leiomyosarcoma in the right parieto-occipital region of a 19-year-old male who had normal clinical and laboratory findings. Diagnostic imaging showed bony destruction, dural involvement and no parenchymal invasion. No primary site was found after metastasis work up. Specific serology tests were negative. The patient underwent a craniotomy, total tumor resection, duraplasty and skull reconstruction. He received radiotherapy and after 18 months of follow-up, no clinical and radiological signs of recurrence have been found.

Objectives: Uterine leiomyosarcoma (LMS) is a rare cancer originated from smooth muscle lining the walls of the uterus, LMS is known as an aggressive tumor with high mortality and morbidity rates compared to other uterine cancers, despite the disease stage at the time of diagnosis, In most cases, LMS has been misdiagnosed as benign uterine leiomyoma following hysterectomy or myomectomy, Case Presentation: We present a 53-year-old G7 L7 woman who was referred to our clinic for abnormal uterine bleeding (AUB) for 6 months, On physical examination, we found an abdominal mass that had grown rapidly in the last 4 months, The computed tomography (CT) scan results showed a heterogeneous mass extending from the epigastric region to the pelvic area, Following an exploratory laparotomy, histopathology report confirmed the diagnosis of LMS, Her uterus, Fallopian tubes and ovaries were removed during a surgery, and she was referred to a gynecologic oncologist for possible chemotherapy, Conclusions: We found that the surgery was the only treatment for LMS, Although there is a faint possibility to diagnose LMS before surgery, in the patient with uncertain diagnosis and suspicious of LMS, analysis of LDH and LDH3 levels along with dynamic gadolinium-diethylenetriamine penta-acetic acid (Gd-DTPA) enhanced magnetic resonance imaging (MRI) is recommended,

Primary paratesticular tumours are rare, and only account for 7% to 10% of all intrascrotal tumours. In adults, more than 75% of these lesions arise from the spermatic cord, and 20% being leiomyosarcoma. In this study we present a rare case of primary paratesticular leiomyosarcoma in a 68 years-old man presenting with a right painless scrotal mass. Scrotal ultrasound showed a solid heterogenic lesion. Tumor markers such as alpha-fetoprotein, lactate dehydrogenase and beta-human chorionic gonadotropin were normal. A right radical orchidectomy confirmed Primary paratrsticular leiomyosarcoma.

Introduction: Uterine leiomyosarcoma (LMS) is a rare cancer originated from smooth muscle lining the walls of the uterus. LMS is known as an aggressive tumor with high mortality and morbidity rates as compared to other uterine cancers, despite the disease stage at the time of diagnosis. In most cases, LMS has been misdiagnosed as a benign uterine leiomyoma following hysterectomy or myomectomy. Case Presentation: We presented a 53-year-old G7 L7 woman who had referred to GYN clinic in Amir-al-Momenin hospital for abnormal uterine bleeding (AUB) for 6 months. On physical examination, we found an abdominal mass that had grown rapidly in the last 4 months. The computed tomography (CT) scan results showed a heterogeneous mass extending from the epigastric region to the pelvic area. Following an exploratory laparotomy, histopathology report confirmed the diagnosis of LMS. Her uterus, Fallopian tubes and ovaries were removed during a surgery, and she was referred to a gynecologic oncologist for possible chemotherapy. Conclusion: We found that the surgery is the only treatment for LMS; however, there is a little possibility to diagnose LMS before surgery in the patient with uncertain diagnosis and suspicious of LMS. Analysis of LDH and LDH3 levels along with dynamic diethylenetriaminepentaacetic acid (Gd-DTPA) enhanced, and MRI are recommended.

Primary leiomyosarcoma in testis is an uncommon tumor with few cases reported. It generally develops after radiotherapy or long-term taking anabolic steroid medication. We report a 53-year-old male patient with primary testis leiomyosarcoma who presented with painless testicular enlargement without any known predisposing factors. Ultrasound revealed a large heterogeneous left testicular solid lesion. Alpha-fetoprotein (AFP) and beta-human chorionic gonadotrophin (beta-HCG) levels in serum were normal. Left radical orchidectomy following with histology assessment established a diagnosis of primary leiomyosarcoma of testis. No data of cancer metastasis was established. The patient didn’ t receive any adjuvant therapy. There wasn’ t any evidence of recurrence after 1 year follow-up. Leiomyosarcoma must be one of the differential diagnoses of seronegative tumors in testis. The motivation for this paper is the extreme infrequency of the situation and the differential diagnosis by all expansive inguinoscrotal tumors.

Herein we report a case of primary leiomyosarcoma of testis, which was believed to originate from normal testicular structures. It contained smooth muscle cells, blood vessels and contractile cells of the seminiferous tubules. No evidence of tumor spread was found. Treatment consisted of orchiectomy with high ligation of the spermatic cord. The patient received no adjuvant therapy and there was no evidence of tumor 30 months after the operation. Pertinent literature is reviewed and the differential diagnosis is discussed.

Leiomyosarcoma is a rare entity in prostate but it is the most common type of prostate sarcomas in adult patients. In most reported series the prognosis is poor and the median survival is about 15-18 months. Hereby we present a 72 years old man who received combined modality treatment including radical surgery followed by adjuvant chemotherapy and radiotherapy. He has been well for 14 months, but now he is suffering from lung metastases and asymptomatic local recurrence