Introduction: Job stress and low job self-efficacy are among the most important job hazards in the modern era. Therefore, this study was conducted with the aim of the effectiveness of self-hypnosis training and ego strengthening on reducing job stress and increasing job selfefficacy of Mashhad girls' primary school teachers. Method: The present study is a quasiexperimental study that was conducted in 1398 on 24 teachers working in girls' primary schools in two groups of self-hypnosis (n = 12) and control (n = 12). The intervention group underwent 3 individual sessions of self-hypnosis training and ego strengthening, each session for 90 minutes once a week. Data were collected by Riggs-Knight Job Self-Efficacy Scale and Cohen Job Stress during three stages before intervention, after intervention and one month later and analyzed using Mancova test. Results: The results showed that the mean scores of job selfefficacy and job stress during the test stages in the self-hypnosis and ego strengthening training groups showed a significant increase and decrease compared to the control group (P <0. 05), respectively. Also, in the follow-up stage after one month, the experimental group showed a significant decrease in job stress compared to the control group compared to the post-test and pre-test (P <0. 05), but in job self-efficacy, no significant difference was observed between the post-test and follow-up. P> 0. 05). Conclusion: According to the research findings, selfhypnosis training and ego strengthening are effective in reducing job stress and increasing job self-efficacy.