This study was conducted to evaluate the risk of carcinogenicity of nickel in vegetables grown in soils treated with different levels of sewage sludge in greenhouse conditions. The experiment was conducted as factorial in a completely randomized design with three replications. Treatments included 5 levels of sewage sludge (0, 1/5, 3, 4, 5 and 6%) and eight types of leafy vegetables (Spinach, Scallion, Radish, Garden cress, Basil, Pearl, Coriander and Savory). The results showed that with increasing levels of sewage sludge, the average daily intake of nickel (ADD) and carcinogenic index increased in both age groups of children and adults (P≤, 0. 0001). So that in treatment of 6% sewage sludge relative to control treatment, for children and adults, 67. 4% and 65. 9% of the increase in carcinogenicity index were calculated respectively. For both age groups, the highest and the lowest index of carcinogenicity of nickel was observed in Garden cress and Pearl, respectively. In general, there was a risk of cancer in both age groups, and children with an average carcinogenic index (CR) of 0. 886, more than tripled, were at increased risk.