EXTRACTION OF TOTAL SAPONIN FROM GLYCYRRHIZA GLABRA AND DETERMINATION OF ITS PHYSICOCHEMICAL PROPERTIES AND COMPLEX FORMATION WITH CHOLESTEROL

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MOGHADAMPOUR E.; KHALILI S.

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Seminar Paper

Paper Information

Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Year:2007 | Issue:18

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Title

EXTRACTION OF TOTAL SAPONIN FROM GLYCYRRHIZA GLABRA AND DETERMINATION OF ITS PHYSICOCHEMICAL PROPERTIES AND COMPLEX FORMATION WITH CHOLESTEROL

Author(s)

MOGHADAMPOUR E. | KHALILI S.

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Abstract

Introduction: Saponins are high molecular weight glycosides which have detergent properties, give stable foams in water, and are used as emulsifiers and fire extinguishers. The recent researches have shown that oral administration of some saponins can prevent hypercholesterolemia; the phenomenon which is the result of complex formation with cholesterol. Glycyrrhiza glabra is a grassy plant which its roots have a high percentage of saponin compounds.Methods and Results: After prepration of the roots and identification as Glycyrrhiza glabra, they were dried, powdered and deffatted with petroleum ether in a suxhlet apparatus. The air-dried powder was successively extracted with methanol, n-butanol and diethyl ether. Then their physicochemical property was determined. Quillaja total saponin and tween80 were used as positive controls. The results showed that total saponin from Glycyrrhiza glabra had a good ability to form stable foam. In addition, in the case of reduction of surface tension and emulsification, the extracted total saponin had less power than the positive control compounds. In the next step, the effect of complex formation with cholesterol of both total saponins, was determined using measuring the changes in surface tension and critical micelle concentrations. The results also showed that the saponins have the ability to form complex with cholesterol.Conclusion: It can be cancluded that oral administration of total saponins from Glycyrrhiza glabra and Quillaja saponaria may cause a reduction in cholesterol absorption in gastrointestinal tract and so a reduction in blood cholesterol. Also due to its excellent surface activity, it can be suggested that the total saponin from the plant roots is a suitable substitute for synthetic surfactants in food, drug and cosmetic industries.

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APA: Copy

MOGHADAMPOUR, E., & KHALILI, S.. (2007). EXTRACTION OF TOTAL SAPONIN FROM GLYCYRRHIZA GLABRA AND DETERMINATION OF ITS PHYSICOCHEMICAL PROPERTIES AND COMPLEX FORMATION WITH CHOLESTEROL. IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY. SID. https://sid.ir/paper/904535/en

Vancouver: Copy

MOGHADAMPOUR E., KHALILI S.. EXTRACTION OF TOTAL SAPONIN FROM GLYCYRRHIZA GLABRA AND DETERMINATION OF ITS PHYSICOCHEMICAL PROPERTIES AND COMPLEX FORMATION WITH CHOLESTEROL. 2007. Available from: https://sid.ir/paper/904535/en

IEEE: Copy

E. MOGHADAMPOUR, and S. KHALILI, “EXTRACTION OF TOTAL SAPONIN FROM GLYCYRRHIZA GLABRA AND DETERMINATION OF ITS PHYSICOCHEMICAL PROPERTIES AND COMPLEX FORMATION WITH CHOLESTEROL,” presented at the IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY. 2007, [Online]. Available: https://sid.ir/paper/904535/en

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