PROTECTIVE EFFECT OF QUERCETIN ON FERROUS SULFATE –INDUCED ACUTE RENAL FAILURE IN RAT

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GHOLAMPOUR FIROZEH; SAKI NADIMEH; BEHZADI GHIASABADI FATEMEH; KEIKHA SAMANEH

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Paper Information

Journal: MOLECULAR BIOLOGY RESEARCH COMMUNICATIONS Year:2014 | Volume:3 | Issue:SUPPL. (1) Page(s): 148-148

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Title

PROTECTIVE EFFECT OF QUERCETIN ON FERROUS SULFATE –INDUCED ACUTE RENAL FAILURE IN RAT

Author(s)

GHOLAMPOUR FIROZEH | SAKI NADIMEH | BEHZADI GHIASABADI FATEMEH | KEIKHA SAMANEH | Issue Writer Certificate

Keywords

QUERCETIN

BLOOD UREA NITROGEN

CREATININE

FERROUS SULFATE

KIDNEY

Abstract

Iron-induced oxidative stress is widely accepted as a critical mediator of diverse forms of glomerular and tubulointerstitial renal disease. Oxidative stress can also exacerbate systemic inflammation. This study was designed to investigate the effects of QUERCETIN, a powerful antioxidant with radical scavenging ability, in FERROUS SULFATE-induced renal injury in rats. The protective effect of QUERCETIN against the damage inflicted by reactive oxygen species (ROS) during renal injury was investigated in male Wistar rats using histopathological and biochemical parameters. Renal injury was induced by i.p. injection of FERROUS SULFATE (30 mg/Kg/day) for 14 days. QUERCETIN (50 mg/kg/day) was injected (i.p.) for 11 days. In final blood samples were collected for later assay of their CREATININE and BLOOD UREA NITROGEN concentration. Thiobarbituric acid reactive substances (TBARS) were determined in renal tissue, and the left KIDNEY was removed and preserved for histological studies. FERROUS SULFATE caused deterioration of renal function, renal morphology and a significant renal oxidative stress. Treatment of animals with QUERCETIN markedly attenuated renal dysfunction, morphological alterations and reduced elevated TBARS levels. The findings imply that ROS play a causal role in FERROUS SULFATE-induced renal injury, and QUERCETIN exerts renoprotective effects probably by the radical scavenging and antioxidant activities.

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APA: Copy

GHOLAMPOUR, FIROZEH, SAKI, NADIMEH, BEHZADI GHIASABADI, FATEMEH, & KEIKHA, SAMANEH. (2014). PROTECTIVE EFFECT OF QUERCETIN ON FERROUS SULFATE –INDUCED ACUTE RENAL FAILURE IN RAT. MOLECULAR BIOLOGY RESEARCH COMMUNICATIONS, 3(SUPPL. (1)), 148-148. SID. https://sid.ir/paper/335972/en

Vancouver: Copy

GHOLAMPOUR FIROZEH, SAKI NADIMEH, BEHZADI GHIASABADI FATEMEH, KEIKHA SAMANEH. PROTECTIVE EFFECT OF QUERCETIN ON FERROUS SULFATE –INDUCED ACUTE RENAL FAILURE IN RAT. MOLECULAR BIOLOGY RESEARCH COMMUNICATIONS[Internet]. 2014;3(SUPPL. (1)):148-148. Available from: https://sid.ir/paper/335972/en

IEEE: Copy

FIROZEH GHOLAMPOUR, NADIMEH SAKI, FATEMEH BEHZADI GHIASABADI, and SAMANEH KEIKHA, “PROTECTIVE EFFECT OF QUERCETIN ON FERROUS SULFATE –INDUCED ACUTE RENAL FAILURE IN RAT,” MOLECULAR BIOLOGY RESEARCH COMMUNICATIONS, vol. 3, no. SUPPL. (1), pp. 148–148, 2014, [Online]. Available: https://sid.ir/paper/335972/en

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