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Information Seminar Paper

Title

BIDIRECTIONAL ROLES OF CYTOKINES IN INDUCTION AND MODULATION OF PAIN DURING DIFFERENT STAGES OF ADJUVANT-INDUCED INFLAMMATION

Pages

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Abstract

 INTRODUCTION: INFLAMMATION IS THE PRIMARY AND, ESSENTIALLY, A SALUTARY RESPONSE THAT NORMALLY RESOLVES WITH THE RESTORATION OF NORMAL TISSUE STRUCTURE AND FUNCTION; HOWEVER, WHEN INFLAMMATION PERSISTS, IT CAN CAUSE TISSUE DAMAGE AND LOSS OF FUNCTION. MODULATION OF PERIPHERAL INFLAMMATORY PAIN BY THE CENTRAL NERVOUS SYSTEM (CNS) MAY BE A PART OF MANY IMMUNOLOGICAL DISEASES HOWEVER; THE MECHANISMS THAT ALLOW THE CNS TO MODULATE PERIPHERAL INFLAMMATORY RESPONSES ARE LARGELY UNKNOWN. PERIPHERAL AND CENTRAL INCREASE IN PROINFLAMMATORY CYTOKINES SUCH AS INTERLEUKIN (IL)-1, IL-6, AND TNF-A ARE CONSIDERED TO PLAY IMPORTANT ROLES IN HYPERALGESIA INDUCTION. MOREOVER IN MOST CASES, THE INFLAMMATORY RESPONSE IS RESOLVED BY THE RELEASE OF ENDOGENOUS ANTI-INFLAMMATORY MEDIATORS (ANTI-INFLAMMATORY CYTOKINES) AS WELL AS THE ACCUMULATION OF INTRACELLULAR NEGATIVE REGULATORY FACTORS. ON THE OTHER HAND, OPIOID RECEPTORS ARE INVOLVED IN THE PAIN MODULATORY SYSTEM DURING INFLAMMATION AND CENTRAL MU-OPIOID RECEPTORS (MORS) ARE MOST ASSOCIATED WITH ANALGESIC THERAPY IN CHRONIC PAIN.RESULTS: OUR PREVIOUS STUDIES DEMONSTRATED THAT SPINAL MOR EXPRESSION INCREASED DURING CHRONIC STAGES OF INFLAMMATION AND IT MAY EMPHASIZE THE IMPORTANT ROLE OF CENTRAL MOR IN MODULATION OF HYPERALGESIA IN INFLAMED VERSUS NON-INFLAMED PERIPHERAL TISSUES. TO OUR CURRENT KNOWLEDGE, CYTOKINES ARE THE MOST POWERFUL SIGNALS THAT INDUCE DE NOVO SYNTHESIS OF THE OPIOID RECEPTORS IN IMMUNE EFFECTOR CELLS AND THAT MODULATE THE EXPRESSION OF THE RECEPTORS IN NEURONAL CELLS.CONCLUSION: IN THIS CASE WE WILL DISCUSS ABOUT THE BIDIRECTIONAL ROLES OF CYTOKINES IN PAIN INDUCTION AND MODULATION DURING DIFFERENT STAGES OF ADJUVANT-INDUCED INFLAMMATION ACCORDING TO OUR PREVIOUS STUDIES.

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    APA: Copy

    ZARINGHALAM, JALAL, & MANAHEJI, HOMA. (2015). BIDIRECTIONAL ROLES OF CYTOKINES IN INDUCTION AND MODULATION OF PAIN DURING DIFFERENT STAGES OF ADJUVANT-INDUCED INFLAMMATION. IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY. SID. https://sid.ir/paper/921060/en

    Vancouver: Copy

    ZARINGHALAM JALAL, MANAHEJI HOMA. BIDIRECTIONAL ROLES OF CYTOKINES IN INDUCTION AND MODULATION OF PAIN DURING DIFFERENT STAGES OF ADJUVANT-INDUCED INFLAMMATION. 2015. Available from: https://sid.ir/paper/921060/en

    IEEE: Copy

    JALAL ZARINGHALAM, and HOMA MANAHEJI, “BIDIRECTIONAL ROLES OF CYTOKINES IN INDUCTION AND MODULATION OF PAIN DURING DIFFERENT STAGES OF ADJUVANT-INDUCED INFLAMMATION,” presented at the IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY. 2015, [Online]. Available: https://sid.ir/paper/921060/en

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