APOPTOTIC EFFECT OF CURCUMIN AND OLEANOLIC ACID ON HUMAN PROSTATE CANCER CELL LINE (DU-145)

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Rajaeian Honjani Simin; SEPEHRI HOURI; DELPHI LADAN

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Seminar Paper

Paper Information

Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Year:2015 | Issue:22

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Title

APOPTOTIC EFFECT OF CURCUMIN AND OLEANOLIC ACID ON HUMAN PROSTATE CANCER CELL LINE (DU-145)

Author(s)

Rajaeian Honjani Simin | SEPEHRI HOURI | DELPHI LADAN

Keywords

PROSTATE CANCER

CURCUMIN

OLEANOLIC ACID

APOPTOSIS

Abstract

INTRODUCTION: PROSTATE CANCER IS THE SECOND MOST COMMON CAUSE OF CANCER-RELATED MORTALITY AMONG MEN. DIET IS A CRITICAL ENVIRONMENTALLY RISK FACTOR IN CANCER DEVELOPMENT. CURCUMIN, A YELLOW PIGMENT DERIVED FROM THE RHIZOME OF HERB CURCUMA LONGA (TURMERIC), HAVE NUMEROUS THERAPEUTIC EFFECTS SUCH AS ANTICANCER ACTIVITY. OLEANOLIC ACID IS A PENTACYCLIC TRITERPENOID COMPOUND WITH A WIDE-SPREAD OCCURRENCE THROUGHOUT THE PLANT KINGDOM AND HAVE ANTI-INFLAMMATORY AND ANTICANCER ACTIVITY.METHODS: ANDROGEN-INDEPENDENT HUMAN PROSTATE CANCER CELL LINE (DU-145) WAS CULTURED IN RPMI 1640 MEDIUM. MTT ASSAY WAS USED TO MEASURE CELLS GROWTH AFTER TREATMENT THE CELLS WITH CURCUMIN AND OLEANOLIC ACID FOR 24H. TO INVESTIGATE APOTOSIS AND IDENTIFY THE CELLS PERCENT THAT WERE ARRESTED IN SUB-G1PHASE, CELL CYCLE DISTRIBUTION WAS ANALYSES BY FLOWCYTOMETRY.RESULTS: OUR RESULTS SHOWED THAT CELLS GROWTH WERE INHIBITED BY CURCUMIN AND OLEANOLIC ACID. INCREASING THE NUMBER OF CELLS IN SUB-G1 PHASE INDICATED THAT THESE CELLS START TO ENTER TO APOPTOSIS. TREATMENT WITH THE COMBINATION OF CURCUMIN AND OLEANOLIC ACID, INHIBITED CELLS GROWTH AND ARRESTED CELLS IN SUB-G1 PHASE MORE, COMPARE TO CURCUMIN AND/ OR OLEANOLIC ACID ALONE.CONCLUSION: COMBINATION OF CURCUMIN AND OLEANOLIC ACID WHICH SYNERGISTICALLY INDUCE APOPTOSIS, COULD INHIBIT PROSTATE CANCER CELLS GROWTH AND COULD BE A GOOD SUBSTITUTION FOR CHEMICAL DRUGS.

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APA: Copy

Rajaeian Honjani, Simin, SEPEHRI, HOURI, & DELPHI, LADAN. (2015). APOPTOTIC EFFECT OF CURCUMIN AND OLEANOLIC ACID ON HUMAN PROSTATE CANCER CELL LINE (DU-145). IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY. SID. https://sid.ir/paper/921563/en

Vancouver: Copy

Rajaeian Honjani Simin, SEPEHRI HOURI, DELPHI LADAN. APOPTOTIC EFFECT OF CURCUMIN AND OLEANOLIC ACID ON HUMAN PROSTATE CANCER CELL LINE (DU-145). 2015. Available from: https://sid.ir/paper/921563/en

IEEE: Copy

Simin Rajaeian Honjani, HOURI SEPEHRI, and LADAN DELPHI, “APOPTOTIC EFFECT OF CURCUMIN AND OLEANOLIC ACID ON HUMAN PROSTATE CANCER CELL LINE (DU-145),” presented at the IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY. 2015, [Online]. Available: https://sid.ir/paper/921563/en

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