In this paper, Clinoptilolite, a natural zeolite from Semnan region, is used to synthesize a catalyst for methanol dehydration to DME. To produce such a catalyst and implement acid sites on the latter, the ionexchange process has been applied. In addition, to optimize the effective factors in the catalyst synthesis process, a L9 Taguchi experimental design has been used. In this design, the effects of four factors have been studied: Ion-exchange solution type (2 levels); Ion-exchange solution concentration; Calcination temperature and calcination time (the last three factors have been studied in 3 levels). The yield of catalyst (conversion * selectivity) has been chosen as the response. To study the effects of these factors on the response, the 9 samples have been tested using a fixed bed reactor. (at T= 350°C, P= 1 atm & WHSV= 4.78 hr-1). The results of the statistical design show that the optimized conditions are calcinations time 3 hours, 2N ammonium chloride, as the ion-exchange solution and calcination temperature at 500°C. The optimized catalyst was tested using a fixed bed reactor at 330° C atm pressure and WHSV= 13.8 hr-1. The results showed 98.1% conversion and 96.5% selectivity. In order to study the catalyst behavior under the industrial operation conditions, the sample was tested in a fixed bed reactor at 300° C 16 bar pressure and WHSV=52.5 hr-1, the results indicated 67.2% conversion and 99.74% selectivity.