The primary aim of this study was to examine the how much the big five personality traits (Neuroticism, Extraversion, Conscientiousness, Agreeableness, & Openness to Experience) and self-esteem could predict eudaimnonic well-being (happiness). 240 University of Tetfran students (89 males and 151 females) completed the Eduaimonic Well-being Scale (Ryff, 1989), The Big Five Inventory (John & Srivastava, 1999), and the Self-Esteem Scale (Rosenberg, 1979). Results showed that the eudemonicwell-being was significantly predicted by Conscientiousness in the both groups, and by Agreeableness and Extraversion only in males. Self-esteem significantly predicted eudaimonic well-being in both sexes, however, its role was more pronounced in females.