The present study examined how positive psychological functioning moderates the effect of acculturation specific and general hassles on the psychological adaptation of 238 Iranian immigrants living in the USA, UK, and Netherlands. Instruments being used were: Hassles checklist (Lay and Nguyen, 1998), Pshchological wellbeing scale (Ryff, 1989) and Health Symptoms Scale (Safdar, et al., 2003). Positive psychological functioning was inversely related to psychophysical symptoms. Acculturation pecific and general hassles were positively associated with psychophysical symptoms, and acculturation specific hassles predicted psychophysical symptoms better than did general hassles. Positive psychological functioning moderated the effect of general, but not acculturation specific, hassles on psychophysical symptoms.