Introduction: Lighting affects many non-visual functions such as Circadian Rhythm, alertness, core body temperature, hormone secretion and sleep. The aim of this study was to investigate the effects of lighting on human cognitive and mental performance in the form of a systematic review.Materials and Methods: in order to access to articles, search was conducted from databases including ISI Web of Knowledge, Scopus, PubMed and Science Direct. The search were done using the keywords "Lighting" and "Illumination" and "Cognitive Performance", "Mental Performance", Memory "", "Attention", "Concentration" by title, keyword and abstracts of articles published in databases mentioned from 2010 to 2016.Results: Lighting is affecting on human performance in three areas of Psycho-cognetive (including visual comfort, visual perception, color recognition, identification of symbols, attention, working memory, learning, reaction time and brain function), Biocognitive area (including alertness, mood, vitality, subjective feelings, motivation and well-being and quality of sleep) and the Mental workload (amount of workload, psychological stress, mental fatigue) is. The best of light is bright daylight in the morning with a short wavelength (wavelength 420-480 nm) and high intensity (1000lx) in the regulation of cognitive processes, biological (circadian rhythm) and mental.Conclusion: Lighting design should be such that in addition to comfort and visual needs, also, it should provide the non-visual and cognitive needs such as attention, alertness, mood, sleep quality and decrease mental fatigue and eventually well-bing.