Introduction: Work-related Musculoskeletal Disorders (WMSDs) occur when the pressure that applied to musculoskeletal tissue is more than tissue tolerant capabilities. This study aimed at assessing the risk factors that cause musculoskeletal disorders associated with manual tasks, using Man TRA, and conducting an ergonomic intervention program (educational engineering) among workers in the printing industry.Methods: In this interventional case-control study, 40 workers, who performed manual tasks, (20 in the case group and 20 in the control group) were chosen and investigated. Nordic Body Map was used to determine the intensity and position of pain in different parts of the body. The Man TRA method was performed to evaluate cumulative scores in four regions of the body (wrist/ hand/ arm, shoulder/ neck, back, and lower limb) for each worker before and after the intervention. Data analysis was done using the SPSS software.Results: Data analysis showed that mean intensity of pain in the control group before and after the intervention in various regions of the body, such as head/neck (P=0.012), right shoulder/arm (P=0.012), left shoulder/arm (P=0.043), back (P=0.003), right hand/ wrist (P=0.028), left hand/wrist (P=0.027), right knee/ hip (P=0.005), left knee/hip (P =0.005), right leg (P=0.012) and left leg (P=0.028) were significant. Cumulative score was also significant in body regions such as arm/wrist/hand (P=0.001) and shoulder/ neck (P=0.001) before and after the interventional program.Conclusions: On the basis of the findings of this study, it could be noted that the ergonomic interventional program was effective for reducing the intensity of pain in various regions of the body and risk factors causing cumulative damage at the workplace.