Introduction & Objective: Infection after orthopedic surgery is one of the most common complications after surgery that causes increases bed occupancy, the length of stay and the cost of patient.This study was done with aim of "determining the effects of various factors on the incidence of surgical site infection in orthopedic patients of Motahari Hospital in Jahrom during 2011".Materials & Methods: This study is a case control study that sampling method used to was compare in 37 patients with postoperative wound infection in orthopedic surgical site and 37 patients without infection.Both groups were matched for age, gender, surgery site, kind of fracture and the same hospital, where they were referred. Through brain storming, focus groups and fishbone diagram, a questionnaire was prepared in three areas; factors related to patients, hospital and accident. Validity and reliability were calculated and found to be 0.88. For data analysis software, the SPSS 16 was used.Results: The mean age of the patients was 36.36±21.18. Eight patients (81.10%) had an infected patient roommate. Independent t tests and chi square showed that there are significant differences between the two groups in Hematoma at the site of trauma, need for blood after surgery, being in the same hospital before surgery, doing invasive care such as suctioning and tracheal tube, need for a dressing at home, days of stay in hospital before surgery, total dose antibiotic prophylaxis and postoperative antibiotic dose, duration of surgery, duration of hospital stay and frequency of dressing change per day in the hospital (P-value<0.05).Conclusions: Although incidence of postoperative infection depend on the incidence of uncontrollable factors such as patient demographics, risk factors, and injury characteristics but Compliance with care protocols before, during and after surgery, helps to prevent the incidence of even worst possible cases of infection.