Backgrounds and Aim: This study aimed to investigate the Prevalence of mood-behavioraldisorders (depression, anxiety, obsessive-compulsive Disorder, phobia) in epileptic patients. Material and Methods: In this study, 42 patients with epilepsy referred to Tohid Hospitalwho were treated with anti-epileptic drugs were evaluated. Epilepsy diagnosed by aneurologist based on history taking, clinical findings and electroencephalography (EEG) wasintroduced. Information collected by self-made questionnaire, and the R-90-SCLquestionnaire. Data were analyzed by using SPSS software, version 21 and by usingdescriptive and analytical statistics (chi-square test, T-test). Results probability level P<0. 05was considered significant. Results: The mean ± SD ages of the participants were 30. 26± 11. 91. Men (36. 9%) andwomen (63. 1%) participate in the study. The relative frequency of mood disorders in casegroup was: depression symptom (54. 8%), generalized anxiety disorder (47. 6%), panic disorder (40. 5%), andobsessive-compulsive disorder (57. 1%). Depression symptom, generalized anxiety disorder and panicdisorder In comparison with the control group was statistically significant (P<0. 05). Findingshowed that in case group there is a significant relationship between depression symptom andobsessive-compulsive disorder with employment status and also Panic disorder and generalizedanxiety disorder had a significant relationship with duration of epilepsy (P<0. 05). Conclusion: According to the results derived from the study, the prevalence of mooddisorders in case group compared to the control group was significant, it is recommended thatepileptic patients receive psychological counseling to decrease the symptom of psychologicaldisorders in interictal phases. More attention to this aspect of epilepsy makes significantreduction in the morbidity and mortality of these patients.