Background & Aims: The role of woman on the one hand as a wife or mother and the other hand as a nurse who working in a stressful environment exposes them to psychological stress of the responsibility.The purpose of the current research was to investigate the relationship between thought rumination and worry as mediators of self-compassion and depression among married female nurses in Ahvaz.Material & Methods: This research was a descriptive-correlational study and 193 married female nurses were selected using stratified proportional sampling method from Imam Khomeini, Golestan, Shafa, Arya and Mehr hospitals of Ahvaz, Iran. Participants completed Beck Depression Inventory-II, Ruminative Response Scale, Penn State Worry Questionnaire, and Self-compassion Scale-short form. The data were analyzed using Pearson correlation coefficient and concurrent hierarchical regression analysis and using SPSS-16 software.Results: Pearson correlation coefficients showed that there were significant negative correlations between selfcompassion with depression, rumination and worry variables and there were significant positive correlations between worry and rumination with depression variables (p<0.05). Also, hierarchical regression analysis by Baron and Kenny method and Sobel test showed that worry and thought rumination are mediators between selfcompassion and depression.Conclusion: In general, the results largely support our models that self-compassion is associated with lower levels of depressive symptoms among women, but the thought ruminations and worries have involved between self-compassion and depressive symptoms.