This article explores the use of independent component analysis (ICA) approach to design a new EEG-based brain-computer interface (BCI) for natural control of prosthetic hand grasp. ICA is a useful technique that allows blind separation of sources, linearly mixed, assuming only the statistical independence of these sources. This suggests the possibility of using ICA to separate different independent brain activities during motor imagery into separate components. This work provides a natural basis for developing an efficient BCI based on single-source data obtained by independent component analysis of multi-channel EEG. The tasks to be discriminated are the imagination of hand grasping and opening and the resting state. Aclassifier is designed for each EEG channel and each source, separately. The features are formed from the 1-s interval of single source computed by ICA and of single-channel EEG data, during each trial of experiment. The mean absolute value, variance, power of beta band, theta band, and alpha band, 1 Hz-spectral components at different frequency band and autoregressive coefficients of order 17 constitute the features. Various feature vectors are formed and are fed into the neural network classifier. The multilayer perceptron (MLP) with back-propagation learning rule is used. The MLP network considered in this study consists of two hidden layers each containing hyperbolic tangent units and two output nodes. The networks were trained with data obtained during 50% of the experimental trials and were validated with data obtained during the subsequent trials. During the training, the feature vector is randomly selected from the training sets and then fed into the network. The learning process is stopped when it is apparent that the generalization performance has peaked. To assess the robustness of the proposed scheme in EEG classification, two different data sets are created for training and evaluating the network. For each of the two data sets obtained during each experiment day, a neural network is trained and evaluated. Then the results are averaged. We observe that single-source which is computed by ICA improved the EEG classification accuracy compared to the Single channel EEG data.