At the first glance, it is clear that the notions of humanism and mysticism are contradictory. Briefly explained, the respective definitions of these two terms result in an impassable (and especially imperfect) symmetry. Defined according to occidental canons, humanism principally valorizes the horizontal relation of man to its kind, meanwhile mysticism make sacred the vertical communion of man and God. The present article proposes to elaborate on, and then go partially beyond, the limits of this apparent dichotomy’ indicating in passage to the ambiguity resulted by the same synthesis. An important part of the article is devoted to the synthetic report (critical in some parts) of our problem. For the rest, there would be a question of extending and completing our synthesis by focusing on the Iranian poet, Sohrab Sepehry, whose collection of poems, Hasht Ketab (Eight Books) present an ideal basis of application for illustrating our hypothesis.