Introduction: The dramatic growth of Web 2. 0 technologies and social networks provides a lot of potential for promoting health and health behavior change programs. Organizations and healthcare providers also play a major role in the use of this tool as the main contributors to these programs. This study aimed to assess published texts to identify opportunities and challenges in the use of social networks in healthcare organizations. Methods: In a systematic review study, we assessed published articles between January 2008 and July 2018 using related keywords in Emerald, ScienceDirect, Springer, Wiley, Magiran, SID, Irandoc and PubMed databases. Results: Fifteen opportunities and six challenges were identified for healthcare organizations. The opportunities for these organizations included informational support, social support, searching for instrumental support, reduction of organizational costs, provision of patient satisfaction, real-time client monitoring, accessing a new atmosphere for communication with clients, educating clients, branding, knowledge management, increased access to specific clients, encouraging behavioral changes, direct communication with clients, instant communication with clients, and identification of opportunities for improving quality within organizations. And also the facing challenges included one-way communication, lack of expertise in the area of information technology and in proper client interaction, protecting the privacy of clients, poor understanding perception of the public, negative comments by patients and ultimately, more follow-ups by other organizations rather than individuals. Conclusion: The identification of the opportunities and challenges provides the possibility of more favorable planning and operation of these networks by policymakers and managers of health organizations.