Introduction: Evaluation of the effect of malocclusion on peers’ judgment and social acceptance of adolescents might be useful in determining orthodontic treatment priorities and its effect on solving social problems and social interactions of adolescents. Therefore this study was undertaken to determine the effect of dental esthetics on social acceptance of 12-15-year-old adolescents as judged by peers in Isfahan in 2016.Materials& Methods: The subjects in this descriptive study consisted of 420 adolescents 1215 years of age in Isfahan. The photographs of two adolescents, of one male and of one female, were used to create 5 versions of each photograph, including normal incisors, protruded incisors, missing lateral incisors, crowded incisors, and midline diastema. Each image was shown to 42 adolescents (21 girls and 21 boys), and their perceptions about every individual's social acceptance were documented in terms of friendship, facial attractiveness, social popularity and leadership ability. Descriptive tests and ANOVA were used for analysis of data. Statistical significance was set at p value<0.05.Results: The highest mean score in friendship (47.1±27.7), social popularity (42.9±31.5), attractiveness (29.6±29.3), and leadership ability (45.9±29.1) was reported for normal occlusion. However, protruded teeth exhibited significantly lower mean scores only in friendship (p value=0.004) and attractiveness (p value=0.03). In the fields of leadership (p value=0.03) and popularity (p value=0.008), there was a significant relationship between the genders of the image and the observer.Conclusion: Based on the results of this study, protruded teeth influenced the judgment of a peer’s social acceptance, including friendship and popularity. Adolescents with normal occlusion enjoyed a higher level of social acceptance. Therefore, to improve adolescents’ social relationships, it is advisable to correct this malocclusion.