The increase of cancer incidence in recent years and its’ negative effects on physical, mental, and social dimensions of human life has caused it to be known as one of the major health problems of the century. The purpose of this study was to investigate the role of emotional expressiveness and fear of intimacy in predicting quality of interpersonal relationship in patients with cancer. The statistical population of this descriptive correlational study consisted of cancer patients who were residents of Yazd, Iran. . According to our defined inclusion criteria, 115 patients were selected by available sampling method. Data collection was done using three questionnaires, namely emotional expressiveness questionnaire developed by King and Emmons, fear of intimacy questionnaire by Descutner and Thelen, and quality of interpersonal relationships questionnaire by Pierce, Sarason, and Sarason. In order to analyze the data, independent Pearson correlation and linear regression methods were used. According to the findings of this study, 49% of the variance in quality of interpersonal relationships in these patients was explained by emotional expressiveness and fear of intimacy. In addition, a significant but negative relationship was found between fear of intimacy and quality of interpersonal relationships. However, we observed a significant and positive relationship between emotional expressiveness and quality of interpersonal relationships in these patients. Due to the importance of the role of emotional expressiveness and fear of intimacy on predicting quality of interpersonal relationships in these patients, the findings of this study can be used for developing and implementing educational and therapeutic programs to enhance patient’ s quality of interpersonal relationships.