In order to study the effect of vermicompost containing copper oxide and zinc oxide nanoparticles on wax beans, an experiment with factorial arrangement were conducted based on a randomized complete block design in three replications. The treatments were as follows: nanoparticles in 4 levels (0, 0.4, 0.8 and 1.2 g/kg weight of substrate), vermicompost in 3 levels (2.5, 5 and 7.5 g/kg-1 weight of substrate) and kind of nanoparticles in 2 levels (copper oxide and zinc oxide). After preparation of substrates, adult worm of Eisenia fetida species was added and after a week nanoparticles solution were added to substrate. After three months, vermicompost prepared according to the weight of cultivation substrate and was mixed with soil; then, wax bean seeds were sowed as a wet planting. Results showed, with increasing copper oxide and zinc oxide nano particles; pod length, number of pod in bush, biological yield, grain yield, harvest index and grain protein decreased and copper and zinc concentration in grain increased. In similar level nanoparticles (except first level), pod length, number of pod in bush, grain yield, weight of hundred grains, stem length and harvest index in zinc oxide nanoparticles were more than copper oxide nanoparticles. The least pod length, number of pod in plant, weight of pod, grain yield and harvest index obtained from the forth level of copper oxide nanoparticle. Also absorption and accumulation of zinc oxide nanoparticles in grain was more than copper oxide nanoparticles.