In issue of resistance economy, there are various and different interpretations in the economic literature. Interpretation that is close to the supreme leader’s perception is “economic flexibility”. In this paper, its literature and theoretical model have been discussed. Then, the risk of context of the national economy and behavior scenarios in the countries as well as quadruplet pillars of economic flexibility will be examined. In next section, concept of resistance economy in Islamic Republic of Iran in light of the viewpoint of the Supreme Leader and a model on resistance economy in Islamic Republic of Iran, which are based on economic growth, economic justice, economic stability and economic flexibility, will be explained. Finally, indices and indicators of quadruplet strategies i.e., confrontation, neutralization, absorption and restoration, distribution and debilitation in light of problem of the West's economic sanctions are introduced.