The purpose of the present research was to study socio-cultural and psychological effective factors contributing to suicide, as well as comparing these factors among Iranian and Tajik women who attempted suicide. The present study was a qualitative study in which 60 patients (30 from each country) participated. Each of these participants went through an in-depth interview. Results of the study showed that the most important factors considering suicide attempt in both groups were as follows: domestic violence, cultural induction, family cold relations, forced marriages, too much responsibility, lack of privacy, polygamy, irrational biases and lack of communication between generations. Tajik men, despite the law of monogamy, prefer polygamy and marry more than one woman. Tajik people also, prohibit burring body of a woman who is dead after a suicide atempt in Muslim cemetery.