Most recently, we read in the news about sending of ricin-exposed letter to some governmental important people. Ricin is a toxalbumin derived from caster bean (Ricinus communis; Euphorbiaceae), whose oil is employed in medicine. Ricin is a potent and highly dangerous protein, where its exposure can cause severe toxicity in different organs and then death. Because there are many possible ways to expose (including skin, mucosal, gastrointestinal and pulmonary routs) and also regarding to its importance, which is abused as a kind of biological killing weapons, and its potential to affect many people via extremely low dosages, the main headlines attributed to its toxicity signs and symptoms, various probable routs of exposure especially via skin and mucosal contacts have been reviewed here. Nevertheless ricin is an easily produced toxin with known application in biological weapons; it is hard to consider it as a quick bio-killing poison to terror someone via exposed letter.