Stress is simply a fact of nature-forces from the outside world affecting the individual. The individual responds to stress in ways that affect the individual as well as their environment. Hence, all living creatures are in a constant interchange with their surroundings (the ecosystem), both physically and behaviorally. This interplay of forces, or energy, is of course present in the relationships between all matter in the universe, whether it is living (animate) or not living (inanimate). However, there are critical differences in how different living creatures relate to their environment. These differences have far-reaching consequences for survival. Because of the overabundance of stress in our modern lives, we usually think of stress as a negative experience, but from a biological point of view, stress can be a neutral, negative, or positive experience. We know that stress of knowledge workers is in organization, and they dislike complexity of work and long mandatory work hours. This dissatisfaction in stress's framework is more in knowledge worker, because of knowledge work is very complex. Stress unsettles balance between knowledge work and knowledge worker in organization, and it affects production of knowledge. There is relationship between stress and productivity. In this paper, we try to review stress and its effects on knowledge workers and focus on strategies for decreasing stress and promotion of knowledge worker productivity.