To explore the effect of different types of Zinc and Manganese fertilization on the quantitative and qualitative yield of wheat, a factorial experiment was carried out in a randomized complete block design with 3 replications in the greenhouse of the research farm of the Faculty of Agriculture, Islamic Azad University, Saveh branch, in November 2008. The factors of this research included 3 levels of soil Manganese consumption, 2 levels of spraying, and 3 levels of soil Zn consumption. The results indicated that the highest grain yield belonged to 5 mgr/kg concentration of soil Manganese consumption and 10 mgr/kg of soil Zn consumption. It was observed that the soil Manganese consumption significantly increased grain yield, 1000 grain weight, the number of grains per spike, and the concentration and quality of Zn and Manganese in shoot, whereas the Manganese spraying only significantly increased the concentration of Manganese and Zn in the grain, the quality of grain Manganese, and the concentration of Manganese and Zn in the shoot. According to the results, the soil Zn consumption significantly increased yield indices, the number of tiller, the concentration and quality of Zn and Manganese in grain, and the concentration of Zn and Manganese in shoot. However, the number of tiller and protein percentage did not significantly improved. Additionally, the results indicated that the application of Zn in the form of spraying compared to the control treatment significantly increased grain yield, the concentration and quality of Zn and Manganese in the grain, and the concentration of Zn and Manganese in the shoot.