Aim: Aim of this study was to determine mediation effects of emotional loneliness on the links of spiritual well-being, social distance, social loneliness and depression in Iranian university students.Method: This study utilized a descriptive correlational design. In this study 251 undergraduate students were selected by availability sampling. All participants were asked to complete the Social Distance Scale(Elmore, 1982), UCLA Loneliness Scale (Russell, 1996), Wadsworth (1986) Scale of Loneliness, Spiritual Well-Being Scale (Paloutzian, & Ellison, 1982) and Zung self-rating depression. The theoretical model was tested within a structural equation–modeling framework to identify both direct and indirect effects.Results: Research findings indicated overall model fit, with both emotional loneliness and spiritual well-being as significant predictors of depression. Although direct effects of social distance and social loneliness were not significant, indirect effect on depression were partially mediated by emotional loneliness. In addition to direct effect of spiritual well-being on depression, it was fully mediated by emotional loneliness. These findings were consistent with the role of loneliness in depression as theoretically proposed.Conclusion: More social distance, and particularly lonelier individuals are more likely to report higher levels of depressive symptoms. In addition, a high personal relationship with God and purpose in life are associated with low depression.Findings emphasize the need to recognize the role of spiritual well-being, social distance, social loneliness and emotional loneliness in predicting depression.