Light weight wood base sandwich panels have certain special properties, the most important of which is a high mechanical strength coupled with its light weight. These panels could replace traditional structural systems in Iran. The purpose of this paper is to investigate the mechanical properties of light weight wood base sandwich panels made from sunflower stalk wastes and particles of poplar layers. To do this, melamine urea formaldehyde resin with ratios of 20:80, 35:65, and 50:50, particles of sunflower stalk, poplar layers wastes with a composition ratio of 0:100, 25:75, 50:50, 75:25, and100:0, and poplar layer of 1.8 millimeter were made for surfaces of panels and manufactured in a one step press. Mechanical test such as modulus of rupture, modulus of elasticity, internal bonding, and compression parallel to board plane were done according to ASTM standards. Results of tests were analyzed with analysis of variance and classification of averages according to Duncan method tests with a reliability of 95%. The results showed the mechanical strengths improved as the melamine-urea formaldehyde ratio increased. Panels with pure sunflower and poplar obtained, respectively, the highest bending strength of 19 and 25 MPa, a modulus of elasticity of 6003 and 8004 MPa, and an internal bond of 0.31 and 0.43 MPa. In conjunction with the parallel pressure resistance, sandwich panels with a core of pure sunflower stalks with 6.9 MPa was the most resistant. Also, strengths were reduced as the ratio of sunflower stalks to particles of poplar layers increased in core layers.