In this study after field observations and XRF analysis of rock samples, statistical and experimental methods have been used to determine the geochemical anomalies of uranium and assessment of correlation between these elements with other elements in anomaly No. 6 of Khoshumi area which is located in structural-sedimentary zone of Central Iran. Therefore, we first normalized the distribution of elements and then calculated the values of MEAN and SATANDARD DEVIATION and after determining the amount of background and threshold of anomalies, the anomaly map of each element have been provided. hence, based upon achieved results the background amount of uranium in this area was 5ppm and its maximum amount calculated 20 ppm which represented uranium anomaly. Moreover, in studied area 3 uranium anomalies have been identified that the most important one is located in the location N0S0 and in anatectic granite and migmatite host rocks and their adjacent propylitic alteration zone. Further, cluster dendrogram analysis, spearman's correlation coefficient and geochemical anomaly maps of the elements have been utilized to determine relationship and correlation between elements and to distinguish the pathfinder elements of uranium. Consequently, uranium has negative correlation with Th, Zr, Sr, Rb, Pb, Ce, Ba and positive correlation with Y, V, Ni, Nb, Zn, Mo, Cu, Cr, Co and two major oxides Fe2o3 and Tio2.