Nowadays, with the increase of terrorist attacks near the urban areas, the building design under the blast loadings is really significant, especially for some important buildings and vital arteries. When an explosion occurs, the blast waves can cause severe damages to the structures and endanger the lives of people. Since the existing steel structures are usually designed to the common gravity and seismic loads, it is necessary to investigate their performances under blast loadings. In this study, analytical studies have been done for 3D structural models of special moment frames (SMF), concentrically braced frames (CBF) and eccentrically braced frames (EBF) with different number of stories 3, 5 and 10. The nonlinear dynamic method is applied for analyzing the models under two different levels of blast loadings. The blast load pattern and other criteria are based on the UFC 3-340-02. The plastic hinge rotation, ductility ratio, performance levels, brace axial forces, shear forces and flexural moments in all models are obtained from the analysis and compared with each others. Based on results, It can be said that the EBF systems generally show the better performances than other systems under blast loadings.