STUDY OF ADJUVANT CAPABILITY OF THE GOLD NANOPARTICLES ON THE IMMUNITY OF BOTULINUM NEUROTOXIN SEROTYPE E IN MOUSE

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

RABIEE RUDSARI A.; EBRAHIMI F.; AREFPOUR TORABI M.A.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Advanced Defense Science and Technology Year:2013 | Volume:4 | Issue:2 (12) Page(s): 87-92

Download Full-Text

Persian Verion

View:

750

Download:

Cites:

Information Journal Paper

Title

STUDY OF ADJUVANT CAPABILITY OF THE GOLD NANOPARTICLES ON THE IMMUNITY OF BOTULINUM NEUROTOXIN SEROTYPE E IN MOUSE

Author(s)

RABIEE RUDSARI A. | EBRAHIMI F. | AREFPOUR TORABI M.A. | Issue Writer Certificate

Keywords

ADJUVANTQ3

BONT/EQ3

GOLD NANOPARTICLESQ3

BOTULISMQ3

RECOMBINANT BINDING DOMAINQ3

Abstract

Botulism is a dangerous neuroparalytic syndrome caused by Clostridium botulinum neurotoxins (serotypes A-G). The more studies have shown that the binding domains in all neurotoxin types (A-G) have a great importance in immunity against the BOTULISM syndrome and nowadays, this domain has been introduced as a vaccine candidate. In this study, for evaluation of ADJUVANT effect of GOLD NANOPARTICLES (GNPs) on a vaccine candidate, the botulinum neurotoxin type E binding domain was used. In vaccine studies one of the problems is the presence of a potent and biocompatible ADJUVANT with fewer side effects. For developing of new ADJUVANTs, the ADJUVANT properties of GNPs to Freund's ADJUVANT (FA) was compared. A RECOMBINANT BINDING DOMAIN BONT/E conjugated with GNPs was prepared and injected four times. The animals were enrolled in two groups, one of which was injected with FA and the other one with GNP-Ag. Then, the antibody titers were compared with each other. Ultimately, the mice were challenged using active BONT/E. The results showed that the immunized mice with GNP-Ag and Ag-FA produced high titers of antibody and presented immune response comparable with together. Regarding antibody induction, challenging results and the GNPs biocompatibility, this kind of nanoparticles might be introduced as a candidate new ADJUVANT in the future studies.

Cites

Immunogenicity evaluation of rBoNT/E nanovaccine after mucosal administration

References

No record.

Cite

APA: Copy

RABIEE RUDSARI, A., EBRAHIMI, F., & AREFPOUR TORABI, M.A.. (2013). STUDY OF ADJUVANT CAPABILITY OF THE GOLD NANOPARTICLES ON THE IMMUNITY OF BOTULINUM NEUROTOXIN SEROTYPE E IN MOUSE. (JOURNAL OF ADVANCED DEFENCE SCIENCE AND TECHNOLOGY) JOURNAL OF PASSIVE DEFENCE SCIENCE AND TECHNOLOGY, 4(2 (12)), 87-92. SID. https://sid.ir/paper/167360/en

Vancouver: Copy

RABIEE RUDSARI A., EBRAHIMI F., AREFPOUR TORABI M.A.. STUDY OF ADJUVANT CAPABILITY OF THE GOLD NANOPARTICLES ON THE IMMUNITY OF BOTULINUM NEUROTOXIN SEROTYPE E IN MOUSE. (JOURNAL OF ADVANCED DEFENCE SCIENCE AND TECHNOLOGY) JOURNAL OF PASSIVE DEFENCE SCIENCE AND TECHNOLOGY[Internet]. 2013;4(2 (12)):87-92. Available from: https://sid.ir/paper/167360/en

IEEE: Copy

A. RABIEE RUDSARI, F. EBRAHIMI, and M.A. AREFPOUR TORABI, “STUDY OF ADJUVANT CAPABILITY OF THE GOLD NANOPARTICLES ON THE IMMUNITY OF BOTULINUM NEUROTOXIN SEROTYPE E IN MOUSE,” (JOURNAL OF ADVANCED DEFENCE SCIENCE AND TECHNOLOGY) JOURNAL OF PASSIVE DEFENCE SCIENCE AND TECHNOLOGY, vol. 4, no. 2 (12), pp. 87–92, 2013, [Online]. Available: https://sid.ir/paper/167360/en

Related Journal Papers